Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide)
- Authors
- Park K.D.; Lee W.K.; Yun J.Y.; Han D.K.; Kim S.H.; Kim Y.H.; Kim H.M.; Kim K.T.
- Issue Date
- 1997
- Publisher
- Elsevier Science Ltd, Oxford, United Kingdom
- Keywords
- Anti-calcification; Sulphonated PEO; Tissue modification; Tissue valve
- Citation
- Biomaterials, v.18, no.1, pp 47 - 51
- Pages
- 5
- Indexed
- SCOPUS
- Journal Title
- Biomaterials
- Volume
- 18
- Number
- 1
- Start Page
- 47
- End Page
- 51
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/38542
- DOI
- 10.1016/S0142-9612(96)00096-8
- ISSN
- 0142-9612
1878-5905
- Abstract
- Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEG-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SO3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEO-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.
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- Appears in
Collections - 2. Clinical Science > Department of Thoracic and Cardiovascular Surgery > 1. Journal Articles
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