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Cited 17 time in webofscience Cited 17 time in scopus
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Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells

Authors
Mander, SunamYou, Dong-JooPark, SumiKim, Dong HwiYong, Hyo JeongKim, Dong-SikAhn, CurieKim, Yun-HeeSeong, Jae YoungHwang, Jong-Ik
Issue Date
Feb-2018
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
Nafamostat mesilate; Triple negative breast cancer; Cell cycle; Metastasis
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.41, no.2, pp 229 - 242
Pages
14
Indexed
SCIE
SCOPUS
KCI
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
41
Number
2
Start Page
229
End Page
242
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3889
DOI
10.1007/s12272-017-0996-9
ISSN
0253-6269
1976-3786
Abstract
Triple-negative breast cancer (TNBC) lacking of oestrogen receptor, progesterone receptor, and epidermal growth factor receptor type 2 is a highly malignant disease which results in a poor prognosis and rare treatment options. Despite the use of conventional chemotherapy for TNBC tumours, resistance and short duration responses limit the treatment efficacy. Therefore, a need exists to develop a new chemotherapy for TNBC. The aim of this study was to examine the anti-cancer effects of nafamostat mesilate (NM), a previously known serine protease inhibitor and highly safe drug on breast cancer cells. Here, we showed that NM significantly inhibits proliferation, migration, and invasion in MDA-MB231 cells, induces G2/M phase cell-cycle arrest, and inhibits the expression of cyclin-dependent kinase 1 (CDK1). Exposure of MDA-MB231 cells to NM also resulted in decreased transcription factor activities accompanied by the regulated phosphorylation of signalling molecules and a decrease in metalloproteinases, the principal modulators of the extracellular environment during cancer progression. Especially, inhibition of TGF beta-stimulated Smad2 phosphorylation and subsequent metastasis-related gene expression, and downregulation of ERK activity may be pivotal mechanisms underlying inhibitory effects of NM on NM inhibits lung metastasis of breast cancer cells and growth of colonized tumours in mice. Taken together, our data revealed that NM inhibits cell growth and metastasis of TNBC cells and indicated that NM is a multi-targeted drug that could be an adjunct therapy for TNBC treatment.
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Kim, Dong-Sik
Anam Hospital (Department of Hepato-Biliary-Pancreatic Surgery, Anam Hospital)
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