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Cited 17 time in webofscience Cited 16 time in scopus
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Clinical implications of pathologic factors after thyroid lobectomy in patients with papillary thyroid carcinoma

Authors
Park, Young MinLee, Doh YoungOh, Kyung HoCho, Jae-GuBaek, Seung-KukKwon, Soon-YoungJung, Kwang-YoonWoo, Jeong-Soo
Issue Date
Dec-2017
Publisher
ELSEVIER SCIENCE BV
Keywords
Pathologic factor; Recurrence; Papillary thyroid carcinoma; Thyroid lobectomy; Microscopic extrathyroidal extension
Citation
ORAL ONCOLOGY, v.75, pp 1 - 5
Pages
5
Indexed
SCI
SCIE
SCOPUS
Journal Title
ORAL ONCOLOGY
Volume
75
Start Page
1
End Page
5
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4367
DOI
10.1016/j.oraloncology.2017.10.012
ISSN
1368-8375
1879-0593
Abstract
Objective: We evaluated the clinical and prognostic significance of pathologic factors by analyzing the treatment results of patients who underwent thyroid lobectomy. Materials and methods: We retrospectively analyzed data from 734 patients diagnosed with papillary thyroid cancer who underwent thyroid lobectomy at Korea University Hospital from January 2004 to December 2016. Results: A total of 734 patients were included in the study and their mean age was 44.5 years (range, 15-83). On univariate analysis, tumor size and recurrence-free survival were significantly related. The 10-year recurrence-free survival was 98.3% for tumors <= 1 cm, 77.8% for > 1 cm and <= 2 cm, and 66.7% for > 2 cm (p = 0.014). Recurrence-free survival was significantly different between patients with and without microscopic extrathyroidal extension (p = 0.002). The 10-year recurrence-free survival rate was 99.2% for patients without extrathyroidal extension and 92.2% for patients with microscopic extrathyroidal extension. Multivariate analysis showed only microscopic extrathyroidal extension was significantly correlated with recurrence-free survival (p = 0.029). Conclusion: In patients undergoing thyroid lobectomy for low-risk papillary thyroid cancer, microscopic extrathyroidal extension was an important prognostic factor associated with recurrence-free survival. However, in cases with microscopic extrathyroidal extension findings on postoperative pathologic examination, appropriate ultrasonographic follow-up of the contralateral thyroid lobe and cervical lymph node to facilitate early detection and prompt treatment of recurrence can control the disease without a deterioration of survival rate.
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Cho, Jae Gu
Guro Hospital (Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital)
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