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Cited 3 time in webofscience Cited 3 time in scopus
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The safety and effectiveness of 2-liter polyethylene glycol plus ascorbic acid in patients with liver cirrhosis: A retrospective observational study

Authors
Lee, Jae MinLee, Jae HyungKim, Eun SunLee, Jung MinYoo, In KyungKim, Seung HanChoi, Hyuk SoonKeum, BoraSeo, Yeon SeokJeen, Yoon TaeLee, Hong SikChun, Hoon JaiUm, Soon HoKim, Chang Duck
Issue Date
Dec-2017
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
ascorbic acid; colonoscopy; liver cirrhosis; polyethylene glycol; safety
Citation
MEDICINE, v.96, no.51
Indexed
SCIE
SCOPUS
Journal Title
MEDICINE
Volume
96
Number
51
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4370
DOI
10.1097/MD.0000000000009011
ISSN
0025-7974
Abstract
The safety of bowel-cleansing agents is an important issue in clinical practice, especially in patients with chronic diseases. Although the safety and efficacy of polyethylene glycol (PEG) has been investigated in many studies, few studies on PEG plus ascorbic acid exist. In this study, we compared the safety of 2 bowel-cleansing agents for patients with liver cirrhosis: 2-liter PEG (2L PEG) plus ascorbic acid versus 4-liter PEG (4L PEG). We performed a retrospective study on colonoscopy in patients with liver cirrhosis. Patients referred for colonoscopy were divided into 2 groups: 2L PEG plus ascorbic acid (n=105) and 4L PEG (n=61). Safety was assessed by comparing the clinical factors and laboratory findings as follows: blood biochemistry, electrolytes, weight change, and bowel-cleansing quality. Serum electrolytes, laboratory findings, and body weight showed no significant change between the 2 groups. There was no significant change in clinical factors before and after bowel preparation in the PEG group or the PEG plus ascorbic acid group. The acceptability and compliance of patients was better in the 2L PEG plus ascorbic acid than the 4L PEG group. In subgroup analysis, patients with compensated or decompensated cirrhosis showed no increased risk of electrolyte imbalances after bowel preparation. Child-Pugh scores did not influence the outcome after bowel cleansing. Successful cleansing was mostly achieved in both groups. Our analysis showed that of the use of 2L PEG plus ascorbic acid could be a safe choice for colonoscopy in patients with liver cirrhosis.
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5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Kim, Seung Han
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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