호지킨림프종에 병발된 간내담관 소멸증후군의 자연관해 1예Spontaneous resolution of vanishing bile duct syndrome in Hodgkin's lymphoma
- Other Titles
- Spontaneous resolution of vanishing bile duct syndrome in Hodgkin's lymphoma
- Authors
- 한우식; 정은석; 김연호; 김청호; 박성철; 이지연; 장윤정; 연종은; 변관수; 이창홍
- Issue Date
- Jun-2005
- Publisher
- Korean Association for the Study of the Liver
- Keywords
- Vanishing bile duct syndrome; Hodgkin’s lymphoma; 간내담관 소멸증후군; 호지킨림프종
- Citation
- The Korean Journal of Hepatology, v.11, no.2, pp 164 - 168
- Pages
- 5
- Indexed
- KCICANDI
- Journal Title
- The Korean Journal of Hepatology
- Volume
- 11
- Number
- 2
- Start Page
- 164
- End Page
- 168
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/43785
- ISSN
- 1226-0479
- Abstract
- [한국어 초록 없음]
Cholestasis in a patient with Hodgkin's disease is uncommon, and the causes of cholestasis are mainly direct tumor involvement of the liver, hepatotoxic effects of drugs, viral hepatitis, sepsis and opportunistic infections. Vanishing bile duct syndrome (VBDS) represents a very rare cause for cholestasis in this disease. We report here on a case of a 45-year-old man who developed VBDS during the complete remission stage of Hodgkin's lymphoma. There was no history of hepatitis or intravenous drug abuse, and the patient had negative results for hepatitis A virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, and human immunodeficiency virus. The serological studies for antinuclear antibodies, anti-mitochondrial antibodies and anti-smooth muscle antibodies were also negative. Liver biopsy disclosed the absence of interlobular bile ducts in 9 of 10 portal tracts without any active lymphocyte infiltration and there were no Reed-Sternberg cell in the liver. The patient's cholestasis was in remission and the serum bililrubin level was normalized after two months without treatment, but tumor recurrence was noted at multiple sites of the abdominal lymph nodes on follow-up abdomino-pelvic computed tomogram.
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