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Cited 12 time in webofscience Cited 16 time in scopus
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Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice

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dc.contributor.authorKim, Tae Hyung-
dc.contributor.authorChoi, Dahee-
dc.contributor.authorKim, Joo Young-
dc.contributor.authorLee, Jeong Hyeon-
dc.contributor.authorKoo, Seung-Hoi-
dc.date.available2020-11-02T08:02:47Z-
dc.date.issued2017-11-28-
dc.identifier.issn1471-230X-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4427-
dc.description.abstractBackground: Acetaminophen (APAP) is a readily available and safe painkiller. However, its overdose is the most common cause of acute liver injury (ALI). Many predisposing factors contribute to susceptibility to APAP-induced ALI. Non-alcoholic fatty liver disease (NAFLD), the major cause of chronic liver disease, is considered an important predictor of APAP-induced ALI, although the exact mechanism controversial. In this study, we aimed to elucidate the effects of NAFLD on APAP-induced ALI. Methods: Two groups of mice, normal chow (NC) diet-fed and fast food (FF) diet-fed mice for 14 weeks, were further divided into two subgroups: intraperitoneally injected with either saline (NC-S and FF-S groups) or APAP (NC-A and FF-A groups). Biochemical tests, histological analysis, quantitative PCR, and western blotting were conducted. Results: Alanine aminotransferase (ALT) level (199.0 +/- 39.0 vs. 63.8 +/- 7.4 IU/L, p < 0.05) and NAFLD activity score (0 vs. 4.5 +/- 0.22) were significantly higher in mice in FF-S group than those in NC-S group. ALI features such as ALT level (8447.8 +/- 1185.3 vs. 836.6 +/- 185.1 IU/L, p < 0.001) and centrizonal necrosis were prominent and mRNA levels of Trib3 (RR, 1.81) was high in mice in the NC-A group. Levels of CYP2E1 and anti-inflammatory molecules such as PPAR-gamma, p62, and NRF2 were high in mice in the FF-A group. Conclusions: Our results showed that while the FF diet clearly induced non-alcoholic steatohepatitis and metabolic syndrome, NAFLD also attenuates APAP-induced ALI by inducing anti-inflammatory molecules such as PPAR-gamma.-
dc.language영어-
dc.language.isoENG-
dc.publisherBMC-
dc.titleFast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1186/s12876-017-0680-z-
dc.identifier.scopusid2-s2.0-85035115764-
dc.identifier.wosid000416213700001-
dc.identifier.bibliographicCitationBMC GASTROENTEROLOGY, v.17-
dc.citation.titleBMC GASTROENTEROLOGY-
dc.citation.volume17-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusPPAR-GAMMA-
dc.subject.keywordPlusINDUCED HEPATOTOXICITY-
dc.subject.keywordPlusUNITED-STATES-
dc.subject.keywordPlusINJURY-
dc.subject.keywordPlusFAILURE-
dc.subject.keywordPlusNRF2-
dc.subject.keywordPlusOVERDOSE-
dc.subject.keywordPlusIMPACT-
dc.subject.keywordPlusNASH-
dc.subject.keywordPlusRATS-
dc.subject.keywordAuthorAcetaminophen-
dc.subject.keywordAuthorNon-alcoholic fatty liver disease-
dc.subject.keywordAuthorDrug-induced liver injury-
dc.subject.keywordAuthorPeroxisome proliferator-activated receptor gamma-
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