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Increased expression of resistin in ectopic endometrial tissue of women with endometriosis

Authors
Oh, Yoon KyungHa, Young RanYi, Kyong WookPark, Hyun TaeShin, Jung-HoKim, TakHur, Jun-Young
Issue Date
Nov-2017
Publisher
WILEY
Keywords
adipokine; endometriosis; inflammation; resistin
Citation
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v.78, no.5
Indexed
SCI
SCIE
SCOPUS
Journal Title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume
78
Number
5
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4517
DOI
10.1111/aji.12726
ISSN
1046-7408
1600-0897
Abstract
ProblemInflammation is a key process in the establishment and progression of endometriosis. Resistin, an adipocytokine, has biological properties linked to immunologic functions, but its role in endometriosis is unclear. Method of studyResistin gene expression was examined in eutopic and ectopic endometrial tissues from women with (n=25) or without (n=25) endometriosis. Resistin mRNA and protein levels were determined in endometrial tissue using quantitative real-time reverse transcription PCR and Western blotting, following adipokine profiling arrays. ResultsResistin protein was detected in human endometrial tissues using an adipokine array test. Resistin mRNA and protein levels were significantly higher in ectopic endometrial tissue of patients with endometriosis than in normal eutopic endometrial tissue. ConclusionOur results indicate that resistin is differentially expressed in endometrial tissues from women with endometriosis and imply a role for resistin in endometriosis-associated pelvic inflammation.
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Hur, Jun Young
Guro Hospital (Department of Obstetrics and Gynecology, Guro Hospital)
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