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Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury

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dc.contributor.authorCho, Wonyong-
dc.contributor.authorSong, Jie-Young-
dc.contributor.authorOh, Se Won-
dc.contributor.authorKim, Myung Gyu-
dc.contributor.authorKo, Yoon Sook-
dc.contributor.authorLee, Hee Yong-
dc.contributor.authorJo, Sang Kyung-
dc.date.available2020-11-02T08:21:27Z-
dc.date.issued2017-10-
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4571-
dc.description.abstractEffective clearance of inflammatory cells is required for resolution of inflammation. Here, we show in vivo evidence that apoptosis and reverse transendothelial migration (rTEM) are important mechanisms in eliminating neutrophils and facilitating recovery following ischemia/reperfusion injury (IRI) of the kidney. The clearance of neutrophils was delayed in the Bax knockout (KO)(BM) -> wild-type (WT) chimera in which bone marrow derived cells are partially resistant to apoptosis, compared to WTBM -> WT mice. These mice also showed delayed functional, histological recovery, increased tissue cytokines, and accelerated fibrosis. The circulating intercellular adhesion molecule-1 (ICAM-1)(+) Gr-1(+) neutrophils displaying rTEM phenotype increased during the recovery phase and blockade of junctional adhesion molecule-C (JAM-C), a negative regulator of rTEM, resulted in an increase in circulating ICAM-1(+) neutrophils, faster resolution of inflammation and recovery. The presence of Tamm-Horsfall protein (THP) in circulating ICAM-1(+) neutrophils could suggest that they are derived from injured kidneys. In conclusion, we suggest that apoptosis and rTEM are critically involved in the clearance mechanisms of neutrophils during the recovery phase of IRI.-
dc.format.extent10-
dc.language영어-
dc.language.isoENG-
dc.publisherKOREAN ACAD MEDICAL SCIENCES-
dc.titleFate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.3346/jkms.2017.32.10.1616-
dc.identifier.scopusid2-s2.0-85029044916-
dc.identifier.wosid000414044100011-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.10, pp 1616 - 1625-
dc.citation.titleJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.citation.volume32-
dc.citation.number10-
dc.citation.startPage1616-
dc.citation.endPage1625-
dc.type.docTypeArticle-
dc.identifier.kciidART002266180-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusCRITICALLY-ILL PATIENTS-
dc.subject.keywordPlusACUTE-RENAL-FAILURE-
dc.subject.keywordPlusTRANSENDOTHELIAL MIGRATION-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusRESOLUTION-
dc.subject.keywordPlusBAX-
dc.subject.keywordPlusPOPULATION-
dc.subject.keywordPlusCONTRIBUTE-
dc.subject.keywordPlusZEBRAFISH-
dc.subject.keywordAuthorIschemia/Reperfusion-
dc.subject.keywordAuthorNeutrophil-
dc.subject.keywordAuthorApoptosis-
dc.subject.keywordAuthorReverse Transendothelial Migration-
dc.subject.keywordAuthorRecovery-
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Cho, Won Yong
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
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