A prospective, multicenter analysis of pseudocapsule characteristics: Do all stages of renal cell carcinoma have complete pseudocapsules?
- Authors
- Cho, Seok; Lee, Jeong Hyeon; Jeon, Seung Hyun; Park, Jinsung; Lee, Sang Hyub; Kim, Chul Hwan; Sung, Ji-Youn; Kim, Joo Heon; Pyun, Jong Hyun; Lee, Jeong Gu; Kim, Je Jong; Cheon, Jun; Kang, Sung Gu; Kang, Seok Ho
- Issue Date
- Jun-2017
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Kidney neoplasms; Partial nephrectomy; Pseudocapsule
- Citation
- UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, v.35, no.6, pp 370 - 378
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Volume
- 35
- Number
- 6
- Start Page
- 370
- End Page
- 378
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4918
- DOI
- 10.1016/j.urolonc.2017.01.003
- ISSN
- 1078-1439
1873-2496
- Abstract
- Objectives: To assess the characteristics of pseudocapsule (PC) in localized renal cell carcinoma (RCC) by analyzing the rates of completeness of PC and pseudocapsular invasion and clinical and pathological risk factors of it. Materials and methods: Between February 2013 and September 2015, data were gathered prospectively from 180 consecutive patients who underwent partial nephrectomy or radical nephrectomy at 3 institutions, and 161 were enrolled. Evaluated factors included age and sex; histologic factors such as tumor diameter, stage, tumor subtype, necrosis, and Fuhrman grade; and clinical factors such as RENAL score; and completeness of PC. Results: Only 94 tumors (58.4%) were surrounded by a continuous PC completely, 62 (38.5%) were partially surrounded, and 5 (3.1%) had no PC. Overall, 56 PCs (34.8%) were free from invasion, 58 PCs (36.0%) had partial invasion of PC without parenchymal invasion, and 47 PCs (29.2%) had parenchymal invasion. Defining parenchymal invasion as true pseudocapsular invasion, histologic diameter, RCC subtype, and completeness of PC were significant predictors for parenchymal invasion on multivariate analysis (P = 0.006, 0.046, and 0.002, respectively). Conclusions: Rate of complete PC in RCC is relatively low in this study. The risk factors for pseudocapsular invasion were a histologic diameter greater than 4 cm, non clear cell histology, and an incomplete PC. Surgeons must prepare for the possibility of a positive surgical margin if a tumor has at least one of these risk factors. (C) 2017 Elsevier Inc. All rights reserved.
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- Appears in
Collections - 2. Clinical Science > Department of Urology > 1. Journal Articles
- 2. Clinical Science > Department of Pathology > 1. Journal Articles
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