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Risk score model for the development of hepatocellular carcinoma in treatment-naive patients receiving oral antiviral treatment for chronic hepatitis B

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dc.contributor.authorSohn, Won-
dc.contributor.authorCho, Ju-Yeon-
dc.contributor.authorKim, Ji Hoon-
dc.contributor.authorLee, Jung Il-
dc.contributor.authorKim, Hyung Joon-
dc.contributor.authorWoo, Min-Ah-
dc.contributor.authorJung, Sin-Ho-
dc.contributor.authorPaik, Yong-Han-
dc.date.available2020-11-02T08:41:44Z-
dc.date.issued2017-06-
dc.identifier.issn2287-2728-
dc.identifier.issn2287-285X-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4965-
dc.description.abstractBackground/Aims: This study aimed to develop and validate a risk prediction model for the development of hepatocellular carcinoma (HCC) in treatment-naive patients receiving oral antiviral treatment for chronic hepatitis B (CHB). Methods: We investigated 2,061 Korean treatment-naive patients with CHB treated with entecavir as an initial therapy. A risk score model for HCC development was developed based on multivariable Cox regression model in a single center (n=990) and was validated using the time-dependent area under the receiver operating characteristic curve (AUROC) in three other centers (n=1,071). The difference of HCC development among risk groups (low, intermediate, and high) categorized by risk score was also investigated. Results: The cumulative incidence rates of HCC at 5 years were 11.2% and 8.9% in the testing and validation cohorts, respectively. HCC-Risk Estimating Score in CHB patients Under Entecavir (HCC-RESCUE) is formulated as (age+15xgender [female=0/male=1]+23xcirrhosis [absence=0/presence=1]). The AUROCs at 1 year, 3 years, and 5 years were 0.82, 0.81, and 0.81, respectively, in the validation cohort. A significant difference of HCC development in each risk group was determined by the 5-year HCC risk score in the validation cohort (low risk group, 2.1%; intermediate risk group, 9.3%; high risk group, 41.2%, p<0.001). Conclusions: The study presents a new risk score model with a good ability to predict HCC development and determine high risk patients for HCC development consisting of readily available clinical factors in treatment-naive CHB patients receiving entecavir.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisherKOREAN ASSOC STUDY LIVER-
dc.titleRisk score model for the development of hepatocellular carcinoma in treatment-naive patients receiving oral antiviral treatment for chronic hepatitis B-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.3350/cmh.2016.0086-
dc.identifier.wosid000407836000011-
dc.identifier.bibliographicCitationCLINICAL AND MOLECULAR HEPATOLOGY, v.23, no.2, pp 170 - 178-
dc.citation.titleCLINICAL AND MOLECULAR HEPATOLOGY-
dc.citation.volume23-
dc.citation.number2-
dc.citation.startPage170-
dc.citation.endPage178-
dc.type.docTypeArticle-
dc.identifier.kciidART002231733-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClassesci-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusPRACTICE GUIDELINES MANAGEMENT-
dc.subject.keywordPlusENTECAVIR TREATMENT-
dc.subject.keywordPlusPREDICTIVE SCORE-
dc.subject.keywordPlusVIRUS INFECTION-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusVALIDATION-
dc.subject.keywordPlusCIRRHOSIS-
dc.subject.keywordAuthorChronic hepatitis B-
dc.subject.keywordAuthorHepatocellular carcinoma-
dc.subject.keywordAuthorAssessment, Risk-
dc.subject.keywordAuthorAntiviral drugs-
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Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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