Neoagarohexaose-mediated activation of dendritic cells via Toll-like receptor 4 leads to stimulation of natural killer cells and enhancement of antitumor immunity
- Authors
- Lee, Moon Hee; Jang, Jong-Hwa; Yoon, Gun Young; Lee, Seung Jun; Lee, Min-Goo; Kang, Tae Heung; Han, Hee Dong; Kim, Hyuk Soon; Choi, Wahn Soo; Park, Won Sun; Park, Yeong-Min; Jung, In Duk
- Issue Date
- 31-May-2017
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Antitumor immunity; Dendritic cells; Natural killer cells; Neoagarohexaose; Toll-like receptor 4
- Citation
- BMB REPORTS, v.50, no.5, pp 263 - 268
- Pages
- 6
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 50
- Number
- 5
- Start Page
- 263
- End Page
- 268
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4978
- DOI
- 10.5483/BMBRep.2017.50.5.014
- ISSN
- 1976-6696
1976-670X
- Abstract
- beta-Agarase cleaves the beta-1,4 linkages of agar to produce neoagarooligosaccharides (NAO), which are associated with various physiological functions. However, the immunological functions of NAO are still unclear. In this study, we demonstrated that beta-agarase DagA-produced neoagarohexaose (DP6), an NAO product, promoted the maturation of dendritic cells (DCs) by Toll-like receptor 4 (TLR4). DP6 directly and indirectly enhanced the activation of natural killer (NK) cells in a TLR4-dependent manner in vitro and in vivo. Finally, the antitumor activity of DP6 against B16F1 melanoma cells was inhibited in NK cell-depletion systems by using NK-cell depleting antibodies in vivo. Collectively, the results indicated that DP6 augments antitumor immunity against B16F1 melanoma cells via the activation of DC-mediated NK cells in a TLR4-dependent manner. Thus, DP6 is a potential candidate adjuvant that acts as an immune cell modulator for the treatment of melanoma.
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- Appears in
Collections - 1. Basic Science > Department of Physiology > 1. Journal Articles
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