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Cited 22 time in webofscience Cited 24 time in scopus
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Approach to cytomegalovirus infections in patients with ulcerative colitis

Authors
Park, Sung ChulJeen, Yoon MiJeen, Yoon Tae
Issue Date
May-2017
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Keywords
Cytomegalovirus; Colitis; ulcerative
Citation
KOREAN JOURNAL OF INTERNAL MEDICINE, v.32, no.3, pp.383 - 392
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
Volume
32
Number
3
Start Page
383
End Page
392
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5031
DOI
10.3904/kjim.2017.087
ISSN
1226-3303
Abstract
Cytomegalovirus (CMV) reactivation is common in patients with severe ulcerative colitis (UC), and may reflect exacerbation of mucosal inflammation and/or administration of immunosuppressants. The question of whether CMV is an active pathogen or 'an innocent bystander' in the exacerbation of UC remains controversial. Patients with UC exacerbated by reactivated CMV experience worse prognoses than those without CMV reactivation and antiviral therapy significantly reduces the need for colectomy in patients with severe UC and high-grade CMV infection, indicating that CMV plays a role in UC prognosis. Therefore, the CMV status of patients on immunosuppressants, particularly those with steroid-refractory or -dependent UC, should be tested. When CMV is detected, be performed based on should adequate treatment the extent of the viral load and the presence of certain clinical features including a large ulcer. Anti-tumor necrosis factor agents may be useful for treating CMV colitis complicating UC.
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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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