Prognostic implication of systemic inflammatory markers in young patients with resectable colorectal cancer
- Authors
- Suk-young Lee; Sun Il Lee; Byung-Wook Min; Sang Cheul Oh
- Issue Date
- Jan-2021
- Publisher
- 대한외과학회
- Keywords
- Colorectal cancer; Prognosis; Systemic inflammatory markers; Young patients
- Citation
- Annals of Surgical Treatment and Research, v.100, no.1, pp 25 - 32
- Pages
- 8
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Annals of Surgical Treatment and Research
- Volume
- 100
- Number
- 1
- Start Page
- 25
- End Page
- 32
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51209
- DOI
- 10.4174/astr.2021.100.1.25
- ISSN
- 2288-6575
2288-6796
- Abstract
- Purpose: The prognosis of young colorectal cancer (CRC) patients has not fully been addressed. The prognostic significance of systemic inflammatory markers was examined in those patients.
Methods: A total of 965 patients with resectable CRC were divided into young (≤ 50 years, n = 101) and old groups (>51 years, n = 864). Neutrophil-to-lymphocyte ratio (NLR) > 5, derived NLR (dNLR) > 3, lymphocyte-to-monocyte ratio (LMR) < 2, platelet-to-lymphocyte ratio (PLR) > 150, and prognostic nutritional index (PNI) < 45 were analyzed for prognosis.
Overall survival (OS) and progression-free survival (PFS) were compared using the log-rank test. A multivariate analysis was performed using a Cox proportional hazards regression model.
Results: In the young group, NLR > 5, LMR < 2, and PNI < 45 were significantly associated with OS with univariate analyses. dNLR > 3 and those markers showed significance for PFS. LMR < 2 was a significant marker for poor PFS (hazard ratio [HR], 5.81; P = 0.020) in the multivariate analysis. In the old group, all inflammatory markers were significantly associated with OS and PFS with univariate analyses. LMR < 2 (HR, 2.66; P = 0.016) and PNI < 45 (HR, 2.14; P = 0.016) were independently associated with OS in multivariate analyses. PLR > 150 (HR, 1.45; P = 0.036) and PNI < 45 (HR, 1.73; P = 0.002) were significant markers for PFS.
Conclusion: Systemic inflammation might be one of biologic factors that influence on prognosis of young CRC.
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- Appears in
Collections - 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
- 2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
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