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곰팡이에 감작된 소아 천식 환자 가정내 환경유해물질 농도와 폐기능의 상관관계The Relationship between Indoor Air Pollutants and Pulmonary Function in Asthmatic Children with Mold Sensitization

Other Titles
The Relationship between Indoor Air Pollutants and Pulmonary Function in Asthmatic Children with Mold Sensitization
Authors
윤원석임재훈박상현이민규유영
Issue Date
Dec-2020
Publisher
한국환경보건학회
Keywords
Asthma; mold; environment; airway hyperresponsiveness; pulmonary function parameters
Citation
한국환경보건학회지, v.46, no.6, pp 685 - 693
Pages
9
Indexed
KCI
Journal Title
한국환경보건학회지
Volume
46
Number
6
Start Page
685
End Page
693
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51246
DOI
10.5668/JEHS.2020.46.6.685
ISSN
1738-4087
Abstract
Objectives: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. The aim of this study was to investigate relationships between indoor mold concentrations and pulmonary function parameters in asthmatic children with mold sensitization. Methods: Asthmatic subjects who had a positive result in skin-prick testing to more than one mold allergen, such as Alternaria, Aspergillus, or Penicillium, were enrolled. Their pulmonary function and methacholine challenge test results were collected. Measurements of blood eosinophil, serum IgE, and fractional exhaled nitric oxide (FeNO) were taken. Indoor levels of VOC, CO2, PM10 and PM2.5 in each subject’s house were measured. We counted mold and bacteria colonies from the subjects’ house air samples. Results: The mean levels of FEV1, FVC, FEV1/FVC, and FEF25-75 were 82.8±19.7, 87.3±17.9, 85.8±8.3, and 82.3±28.9%, respectively. The mean FeNO level was 19.8±11.2 ppb and the geometric mean (range of one SD) of methacholine PC20 was 3.99 mg/mL (0.67-23.74 mg/mL). The average indoor air pollutant levels were below the recommended levels set by the Ministry of Environment for multiplex buildings. Indoor mold levels showed a significant inverse correlation with methacholine PC20, but not with the baseline pulmonary function parameters. Conclusion: Indoor mold concentrations are a risk factor for increased bronchial hyperresponsiveness among asthmatic children with mold sensitization. Targeted environmental intervention should be considered for selected asthmatic children with mold sensitization for avoiding severe airway hyperresponsiveness.
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2. Clinical Science > Department of Pediatrics > 1. Journal Articles
4. Research institute > Institute for Healthcare Service Innovation > 1. Journal Articles
4. Research institute > Allergy Immunology Center > 1. Journal Articles

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