Prevention of benign paroxysmal positional vertigo with vitamin D supplementation A randomized trial
- Authors
- Jeong, Seong-Hae; Kim, Ji-Soo; Kim, Hyo-Jung; Choi, Jeong-Yoon; Koo, Ja-Won; Choi, Kwang-Dong; Park, Ji-Yun; Lee, Seung-Han; Choi, Seo-Young; Oh, Sun-Young; Yang, Tae-Ho; Park, Jae Han; Jung, Ileok; Ahn, Soyeon; Kim, Sooyeon
- Issue Date
- Sep-2020
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Citation
- Neurology, v.95, no.9, pp E1117 - E1125
- Indexed
- SCIE
SCOPUS
- Journal Title
- Neurology
- Volume
- 95
- Number
- 9
- Start Page
- E1117
- End Page
- E1125
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51286
- DOI
- 10.1212/WNL.0000000000010343
- ISSN
- 0028-3878
1526-632X
- Abstract
- Objective To assess the effect of vitamin D and calcium supplementation in preventing recurrences of benign paroxysmal positional vertigo (BPPV). Methods We performed an investigator-initiated, blinded-outcome assessor, parallel, multicenter, randomized controlled trial in 8 hospitals between December 2013 and May 2017. Patients with confirmed BPPV were randomly assigned to the intervention (n = 518) or the observation (n = 532) group after successful treatment with canalith repositioning maneuvers. The primary outcome was the annual recurrence rate (ARR). Patients in the intervention group had taken vitamin D 400 IU and 500 mg of calcium carbonate twice a day for 1 year when serum vitamin D level was lower than 20 ng/mL. Patients in the observation group were assigned to follow-ups without further vitamin D evaluation or supplementation. Results The intervention group showed a reduction in the ARR (0.83 [95% confidence interval (CI), 0.74-0.92] vs 1.10 [95% CI, 1.00-1.19] recurrences per 1 person-year) with an incidence rate ratio of 0.76 (95% CI, 0.66-0.87,p< 0.001) and an absolute rate ratio of -0.27 (-0.40 to -0.14) from intention-to-treat analysis. The number needed to treat was 3.70 (95% CI, 2.50-7.14). The proportion of patients with recurrence was also lower in the intervention than in the observation group (37.8 vs 46.7%,p= 0.005). Conclusions Supplementation of vitamin D and calcium may be considered in patients with frequent attacks of BPPV, especially when serum vitamin D is subnormal. Classification of evidence This study provides Class III evidence that for patients with BPPV, vitamin D and calcium supplementation reduces recurrences of BPPV.
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Collections - 2. Clinical Science > Department of Neurology > 1. Journal Articles
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