Detailed Information

Cited 43 time in webofscience Cited 57 time in scopus
Metadata Downloads

A prospective multicenter study of submucosal injection to improve endoscopic snare papillectomy for ampullary adenoma

Full metadata record
DC FieldValueLanguage
dc.contributor.authorHyun, Jong Jin-
dc.contributor.authorLee, Tae Hoon-
dc.contributor.authorPark, Jin-Seok-
dc.contributor.authorHan, Joung-Ho-
dc.contributor.authorJeong, Seok-
dc.contributor.authorPark, Seon Mee-
dc.contributor.authorLee, Hong Sik-
dc.contributor.authorMoon, Jong Ho-
dc.contributor.authorPark, Sang-Heum-
dc.date.available2020-11-02T08:50:14Z-
dc.date.issued2017-04-
dc.identifier.issn0016-5107-
dc.identifier.issn1097-6779-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5148-
dc.description.abstractBackground and Aims: Whether or not submucosal injection of a diluted epinephrine solution should be used to lift ampullary tumors during endoscopic snare papillectomy is unclear. This study aimed to investigate the clinical efficacy of a simple snaring method versus submucosal injection for papillectomy. Methods: A prospective multicenter study was performed at 4 tertiary referral centers. Patients with papillary lesions were randomized to undergo either simple snare papillectomy (SSP) or submucosal injection papillectomy (SIP) using 1: 10,000 diluted epinephrine. The main outcome measures were complete resection rate and post-papillectomy adverse events. Results: A total of 50 patients with biopsy-proven papillary adenomas were enrolled. Complete resection rates in the SSP and SIP groups were 80.8% (21/26) and 50.0% (12/24), respectively (P = .02). However, tumor persistence at 1 month (15.4% vs 8.3%, P = .62) and recurrence at 12 months (12.0% vs 9.5%, P = .58) did not differ despite initial differences in the prevalence of a positive resection margin. The mean tumor size was 12 mm in the SSP group and 9.29 mm in the SIP group. Post-papillectomy bleeding developed in 42.3% (11/26) and 45.8% (11/24) of patients, respectively (P = .80). Delayed bleeding (>12 h) occurred in 27.3% (3/11) and 36.4% (4/11) of patients, respectively (P = .50). Post-procedure pancreatitis occurred in 15.4% (4/26) and 25% (6/24) of patients, respectively (P = .49). Pancreatitis severity did not differ between the groups, and there were no procedure-related mortalities. Conclusions: Although the recurrence rate was similar between the SSP and SIP groups, SIP showed no advantage over SSP in terms of achieving complete resection or decreasing the frequency of post-papillectomy adverse events, such as bleeding. SSP may thus be a simpler and primarily recommendable technique. (Clinical trial registration number: NCT02165852.)-
dc.format.extent10-
dc.language영어-
dc.language.isoENG-
dc.publisherMOSBY-ELSEVIER-
dc.titleA prospective multicenter study of submucosal injection to improve endoscopic snare papillectomy for ampullary adenoma-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1016/j.gie.2016.08.013-
dc.identifier.scopusid2-s2.0-85001022726-
dc.identifier.wosid000401104700010-
dc.identifier.bibliographicCitationGASTROINTESTINAL ENDOSCOPY, v.85, no.4, pp 746 - 755-
dc.citation.titleGASTROINTESTINAL ENDOSCOPY-
dc.citation.volume85-
dc.citation.number4-
dc.citation.startPage746-
dc.citation.endPage755-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusMAJOR DUODENAL PAPILLA-
dc.subject.keywordPlusBENIGN-TUMORS-
dc.subject.keywordPlusVATER-
dc.subject.keywordPlusMANAGEMENT-
dc.subject.keywordPlusCARCINOMA-
dc.subject.keywordPlusCOMPLICATIONS-
dc.subject.keywordPlusEXCISION-
dc.subject.keywordPlusTHERAPY-
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Hong Sik photo

Lee, Hong Sik
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE