Triglyceride and glucose index and the risk of gestational diabetes mellitus: A nationwide population-based cohort study
- Authors
- Kim, Jung A; Kim, Jinsil; Roh, Eun; Hong, So-hyeon; Lee, You-Bin; Baik, Sei Hyun; Choi, Kyung Mook; Noh, Eunjin; Hwang, Soon Young; Cho, Geum Joon; Yoo, Hye Jin
- Issue Date
- Jan-2021
- Publisher
- Elsevier Ireland Ltd
- Keywords
- Gestational diabetes mellitus; Glucose; Triglyceride; Triglyceride-glucose index
- Citation
- Diabetes Research and Clinical Practice, v.171
- Indexed
- SCIE
SCOPUS
- Journal Title
- Diabetes Research and Clinical Practice
- Volume
- 171
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51682
- DOI
- 10.1016/j.diabres.2020.108533
- ISSN
- 0168-8227
1872-8227
- Abstract
- Aims: Pre-pregnancy insulin resistance is one of the main pathophysiologies of gestational diabetes mellitus (GDM). Triglyceride-glucose (TyG) index is a marker of insulin resistance. We aimed to evaluate the association between pre-pregnancy TyG index and GDM in primipara women.
Methods: A total of 380,208 women who underwent a Korean national health screening exam within 2 years before their first delivery, between January 1, 2012 and December 31, 2015, were included. The TyG index was calculated as In [triglyceride (mg/dL) x fasting plasma glucose (mg/dL)/2].
Results: Among the 380,208 primipara women, 17,239 women were diagnosed with GDM (4.53%). Multivariate logistic regression analysis adjusted for risk factors showed a higher odds ratio of 1.73 for GDM (95% CI 1.65-1.81) in the highest quartile than that in the lowest quartile. A 1-SD increase in the TyG index increased the risk of GDM (31%) and GDM requiring insulin therapy (82%) in the fully adjusted model. A 1-unit increase in the TyG index significantly increased the risk of GDM and GDM requiring insulin treatment by 1.81 and 3.69 times, respectively.The impact of a high TyG index on the risk of GDM was more profound in the subjects aged >= 35 years, with obesity, with impaired fasting glucose, who are current smokers, and with a family history of diabetes mellitus.
Conclusions: Increased pre-pregnancy TyG index is associated with a risk of GDM. Elevation of the TyG index may be an early marker of GDM. (C) 2020 Elsevier B.V. All rights reserved.
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Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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- 2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles
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