Beware of Early Relapse in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy
- Authors
- Oh, Seul-Gi; Park, In Ja; Seo, Ji-Hyun; Kim, Young Il; Lim, Seok-Byung; Kim, Chan Wook; Yoon, Yong Sik; Lee, Jong Lyul; Yu, Chang Sik; Kim, Jin Cheon
- Issue Date
- Dec-2020
- Publisher
- KOREAN SOC COLOPROCTOLOGY
- Keywords
- Rectal neoplasms; Early recurrence; Preoperative chemoradiotherapy; Surveillance; Recurrence pattern
- Citation
- ANNALS OF COLOPROCTOLOGY, v.36, no.6, pp 382 - 389
- Pages
- 8
- Indexed
- SCOPUS
ESCI
KCI
- Journal Title
- ANNALS OF COLOPROCTOLOGY
- Volume
- 36
- Number
- 6
- Start Page
- 382
- End Page
- 389
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51811
- DOI
- 10.3393/ac.2020.06.11
- ISSN
- 2287-9714
2287-9722
- Abstract
- Purpose: Recurrence patterns in rectal cancer patients treated with preoperative chemoradiotherapy (PCRT) are needed to evaluate for establishing tailored surveillance protocol. Methods: This study included 2,215 patients with locally-advanced mid and low rectal cancer treated with radical resection between January 2005 and December 2012. Recurrence was evaluated according to receipt of PCRT; PCRT group (n=1,258) and no-PCRT group (n=957). Early recurrence occurred within 1 year of surgery and late recurrence after 3 years. The median follow-up duration was 65.7 +/- 29 months. Results: The overall recurrence rate was similar between the PCRT and no-PCRT group (25.8% vs. 24.9%, P=0.622). The most common initial recurrence site was the lungs in both groups ( 50.6% vs. 49.6%, P=0.864), followed by the liver, which was more common in the no-PCRT group (22.5% vs. 33.6%, P=0.004). Most of the recurrence occurred within 3 years after surgery in both groups (85.3% vs. 85.8%, P=0.862). Early recurrence was more common in the PCRT group than in the no-PCRT group (43.1% vs. 32.4%, P=0.020). Recurrence within the first 6 months after surgery was significantly higher in the PCRT group than in the no-PCRT group (18.8% vs. 7.6%, P=0.003). Lung (n=27, 44.3%) and liver (n=22, 36.1%) were the frequent the first relapsed site within 6 months after surgery in PCRT group. Conclusion: Early recurrence within the first 1 year after surgery was more common in patients treated with PCRT. This difference would be considered for surveillance protocols and need to be evaluated in further studies.
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- Appears in
Collections - 2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
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