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Helicobacter pylori Eradication in Drug-related Peptic Ulcer

Authors
Joo, M.K.
Issue Date
May-2020
Publisher
NLM (Medline)
Keywords
Anti-inflammatory agents; Aspirin; Helicobacter pylori; non-steroidal; Peptic ulcer
Citation
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.76, no.5, pp.227 - 231
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume
76
Number
5
Start Page
227
End Page
231
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51913
DOI
10.4166/kjg.2020.141
ISSN
1598-9992
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin are the most frequently prescribed drugs worldwide, and their long-term use often leads to peptic ulcers (PUs) along with serious complications, such as bleeding and perforation. Helicobacter pylori (H. pylori) infection is a significant risk factor for developing NSAID-related PU and ulcer bleeding during long-term aspirin use. In a revised version of the Clinical Guidelines for Drug-induced Peptic Ulcer, two statements regarding H. pylori eradication are recommended. 1) Patients scheduled for long-term NSAID therapy should be tested and treated for H. pylori infection to prevent PU and its complications. 2) Patients with a history of PU receiving long-term low-dose aspirin (LDA) therapy should undergo treatment for H. pylori infection to prevent PU and its complications. On the other hand, unlike NSAID-naïve patients, the preventive effects of H. pylori eradication in chronic NSAID users are unclear. In addition, anti-ulcer drugs, such as proton pump inhibitors, may be necessary for maintenance therapy after H. pylori eradication in a subset of long-term LDA users, particularly if the patients are taking concomitant antiplatelet agents or anticoagulants.
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Joo, Moon Kyung
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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