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Current status of breast implant-associated anaplastic large cell lymphoma in South Koreaopen access유방보형물 연관 역형성대세포림프종의 국내 현황

Other Titles
유방보형물 연관 역형성대세포림프종의 국내 현황
Authors
Yoon, Eul-Sik
Issue Date
Jan-2021
Publisher
대한의사협회
Keywords
Breast implants; Anaplastic large cell lymphoma; Pathophysiology; Prognosis; Treatment
Citation
Journal of the Korean Medical Association, v.64, no.1, pp 5 - 9
Pages
5
Indexed
SCOPUS
ESCI
KCI
Journal Title
Journal of the Korean Medical Association
Volume
64
Number
1
Start Page
5
End Page
9
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51946
DOI
10.5124/jkma.2021.64.1.5
ISSN
1975-8456
2093-5951
Abstract
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a unique type of lymphoma caused by breast implants. Concerns about BIA-ALCL have increased worldwide, and three domestic cases have been reported in South Korea. However, the incidence of the disease is not clear, and the risk probability has been reported to be up to 1/3,000. The most important factor in BIA-ALCL is the texturing of the implanted devices. Since the type of texturing is heterogeneous among products and companies, it is important for physicians to be aware of the spectrum of products and their implied risk. The pathophysiology of BIA-ALCL is presumed to be a combination of chronic inflammation related to the microenvironment and genetic predisposition. Further studies will allow accurate diagnosis and prognosis of the disease. The prognosis of BIA-ALCL is favorable if patients with late seroma or pericapsular masses are diagnosed early and complete surgical removal is achieved. Accurate diagnosis includes cytology or pathology with immunohistochemistry, including the CD30 protein and anaplastic lymphoma kinase. An essential factor in surgical success is radical excision with total capsulectomy. However, there is no evidence for prophylactic removal of a textured implant without symptoms. Careful examination and consultation should precede the implant removal, which can lead to deformity or complications. Domestic collaboration among healthcare providers for diagnosis and treatment is needed along with active reporting and registration of suspected patients. Finally, worldwide cooperation and improved awareness leading to regular surveillance are crucial in the era of BIA-ALCL.
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Yoon, Eul Sik
Anam Hospital (Department of Plastic and Reconstructive Surgery, Anam Hospital)
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