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Cited 8 time in webofscience Cited 4 time in scopus
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Longitudinal symptom network structure in first-episode psychosis: A possible marker for remission

Authors
Piao, Yan HongYun, Je-YeonNguyen, Thong BaKim, Woo-SungSui, JingKang, Nam-InLee, Keon-HakRyu, SeunghyongKim, Sung-WanLee, Bong JuKim, Jung JinYu, Je-ChunLee, Kyu YoungWon, Seung-HeeLee, Seung-HwanKim, Seung-HyunKang, Shi HyunKim, EuitaeChung, Young Chul
Issue Date
Oct-2022
Publisher
Cambridge University Press
Keywords
First-episode psychosis; network analysis; prediction; remission
Citation
Psychological Medicine, v.52, no.14, pp 3193 - 3201
Pages
9
Indexed
SCIE
SSCI
SCOPUS
Journal Title
Psychological Medicine
Volume
52
Number
14
Start Page
3193
End Page
3201
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/51963
DOI
10.1017/S0033291720005280
ISSN
0033-2917
1469-8978
Abstract
Background Network approach has been applied to a wide variety of psychiatric disorders. The aim of the present study was to identify network structures of remitters and non-remitters in patients with first-episode psychosis (FEP) at baseline and the 6-month follow-up. Methods Participants (n = 252) from the Korean Early Psychosis Study (KEPS) were enrolled. They were classified as remitters or non-remitters using Andreasen's criteria. We estimated network structure with 10 symptoms (three symptoms from the Positive and Negative Syndrome Scale, one depressive symptom, and six symptoms related to schema and rumination) as nodes using a Gaussian graphical model. Global and local network metrics were compared within and between the networks over time. Results Global network metrics did not differ between the remitters and non-remitters at baseline or 6 months. However, the network structure and nodal strengths associated with positive-self and positive-others scores changed significantly in the remitters over time. Unique central symptoms for remitters and non-remitters were cognitive brooding and negative-self, respectively. The correlation stability coefficients for nodal strength were within the acceptable range. Conclusion Our findings indicate that network structure and some nodal strengths were more flexible in remitters. Negative-self could be an important target for therapeutic intervention.
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Kim, Seung Hyun
Guro Hospital (Department of Psychiatry, Guro Hospital)
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