Human placenta-derived mesenchymal stem cells induce trophoblast invasion via dynamic effects on mitochondrial function
- Authors
- Seok, Jin; Jun, Sujin; Cho, Jinki; Park, Sohea; Lee, Jung Ok; Kim, Gi Jin
- Issue Date
- Sep-2021
- Publisher
- WILEY
- Keywords
- invasion; mitochondria; mitochondrial autophagy; placenta-derived mesenchymal stem cells; trophoblast
- Citation
- JOURNAL OF CELLULAR PHYSIOLOGY, v.236, no.9, pp 6678 - 6690
- Pages
- 13
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CELLULAR PHYSIOLOGY
- Volume
- 236
- Number
- 9
- Start Page
- 6678
- End Page
- 6690
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52115
- DOI
- 10.1002/jcp.30330
- ISSN
- 0021-9541
1097-4652
- Abstract
- The trophoblast is a critical cell for placental development and embryo implantation in the placenta. We previously reported that placenta-derived mesenchymal stem cells (PD-MSCs) increase trophoblast invasion through several signaling pathways. However, the paracrine effects of PD-MSCs on mitochondrial function in trophoblasts are still unclear. Therefore, the objective of the study was to analyze the mitochondrial function of trophoblasts in response to cocultivation with PD-MSCs. The results showed that PD-MSCs regulate the balance between cell survival and death and protect damaged mitochondria in trophoblasts from oxidative stress. Moreover, PD-MSCs upregulate factors involved in mitochondrial autophagy in trophoblast cells. Finally, PD-MSCs improve trophoblast invasion. Taken together, the data indicate that PD-MSCs can regulate trophoblast invasion through dynamic effects on mitochondrial energy metabolism. These results support the fundamental role of mitochondrial energy mechanism in trophoblast invasion and suggest a new therapeutic strategy for infertility.
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- Appears in
Collections - 1. Basic Science > Department of Anatomy > 1. Journal Articles
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