Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)

Rost, Natalia S.; Giugliano, Robert P.; Ruff, Christian T.; Murphy, Sabina A.; Crompton, Andrea E.; Norden, Andrew D.; Silverman, Scott; Singhal, Aneesh B.; Nicolau, Jose C.; SomaRaju, Bhupathi; Mercuri, Michele F.; Antman, Elliott M.; Braunwald, Eugene; ENGAGE AF-TIMI 48 Investigators; Vogelmann, O.; Gonzalez, C.; Ahuad Guerrero, R.; Rodriguez, M.; Albisu, J.; Rosales, E.; Allall, O.; Reguero, M.; Alvarez, C.; Garcia, M.; Ameriso, S.; Ameriso, P.; Amuchastegui, M.; Caceres, M.; Beloscar, J.; Petrucci, J.; Berli, M.; Budassi, N.; Valle, M.; Bustamante Labarta, G.; Saravia, M.; Caccavo, A.; Fracaro, V.; Cartasegna, L.; Novas, V.; Caruso, O.; Saa Zarandon, R.; Colombo, H.; Morandini, M.; Cuello, J.; Rosell, M.; Cuneo, C.; Bocanera, M.; D&apos;Amico, A.; Cendali, G.; Dran, R.; Moreno, V.; Estol, C.; Davolos, M.; Facello, A.; Facello, M.; Falu, E.; Iriarte, M.; Femenia, F.; Arrieta, M.; Fuselli, J.; Zanotti, A.; Gant Lopez, J.; Meiller, F.; Garcia Duran, R.; Perlo, D.; Garrido, M.; Ceirano, C.; Giacomi, G.; Eden, M.; Giannaula, R.; Huerta, M.; Goicoechea, R.; von Wulffen, M.; Hominal, M.; Bianchini, M.; Jure, H.; Jure, D.; Kevorkian, R.; Monaco, F.; Lanternier, G.; Belcuore, M.; Liniado, G.; Iglesias, M.; Litvak, B.; Nigro, A.; Llanos, J.; Vignau, S.; Lorente, C.; Shatsky, K.; Lotti, J.; Raimondi, G.; Mackinnon, I.; Carne, M.; Manuale, O.; Calderon, M.; Marino, J.; Funes, I.; Muntaner, J.; Gandur, H.; Nul, D.; Verdini, E.; Piskorz, D.; Tommasi, A.; Povedano, G.; Casares, E.; Pozzer, D.; Fernandez, E.; Prado, A.; Venturini, C.; Ramos, H.; Navarrete, S.; Rodriguez, M.; Alvarez, M.; Sanchez, A.; Bowen, L.; Sanjurjo, M.; Codutti, O.; Saravia Toledo, S.; Formoso, I.; Schmidberg, J.; Goloboulicz, A.; Schygiel, P.; Buzzetti, C.; Severino, P.; Morara, P.; Sosa Liprandi, M.; Teves, M.; Vico, M.; Morell, Y.; Anderson, C.; Anderson, C.; Paraskevaidis, T.; Arstall, M.; Hoffmann, B.; Colquhoun, D.; Price-Smith, S.; Crimmins, D.; Slattery, A.; Dart, A.; Kay, S.; Davis, S.; Silver, G.; Flecknoe-Brown, S.; Roberts, J.; Gates, P.; Jones, S.; Lehman, R.; Morrison, H.; McKeirnan, M.; Li, J.; Paul, V.; Batta, C.; Purnell, P.; Perrett, L.; Szto, G.; O&apos;Shea, V.; Capiau, L.; Banaeian, F.; De Bleecker, J.; de Koning, K.; De Tollenaere, M.; De Bruyne, L.; Desfontaines, P.; Tincani, G.; Heidbuchel, H.; Meeusen, K.; Herzet, J.; Malmendier, D.; Mairesse, G.; Raepers, M.; Parque, J.; Clinckemaille, N.; Scavee, C.; Huyberechts, D.; Stockman, D.; Jacobs, C.; Vandekerckhove, Y.; Derycker, K.; Vanwelden, J.; van Welden, J.; Vervoort, G.; Mestdagh, I.; Vrolix, M.; Beerts, C.; Wollaert, B.; Denie, D.; Vincenzo de Paola, A. 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doi:10.1161/STROKEAHA.116.013540

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Cited 76 time in webofscience

Cited 83 time in scopus

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Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)

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DC Field	Value	Language
dc.contributor.author	Rost, Natalia S.	-
dc.contributor.author	Giugliano, Robert P.	-
dc.contributor.author	Ruff, Christian T.	-
dc.contributor.author	Murphy, Sabina A.	-
dc.contributor.author	Crompton, Andrea E.	-
dc.contributor.author	Norden, Andrew D.	-
dc.contributor.author	Silverman, Scott	-
dc.contributor.author	Singhal, Aneesh B.	-
dc.contributor.author	Nicolau, Jose C.	-
dc.contributor.author	SomaRaju, Bhupathi	-
dc.contributor.author	Mercuri, Michele F.	-
dc.contributor.author	Antman, Elliott M.	-
dc.contributor.author	Braunwald, Eugene	-
dc.contributor.author	ENGAGE AF-TIMI 48 Investigators	-
dc.contributor.author	Vogelmann, O.	-
dc.contributor.author	Gonzalez, C.	-
dc.contributor.author	Ahuad Guerrero, R.	-
dc.contributor.author	Rodriguez, M.	-
dc.contributor.author	Albisu, J.	-
dc.contributor.author	Rosales, E.	-
dc.contributor.author	Allall, O.	-
dc.contributor.author	Reguero, M.	-
dc.contributor.author	Alvarez, C.	-
dc.contributor.author	Garcia, M.	-
dc.contributor.author	Ameriso, S.	-
dc.contributor.author	Ameriso, P.	-
dc.contributor.author	Amuchastegui, M.	-
dc.contributor.author	Caceres, M.	-
dc.contributor.author	Beloscar, J.	-
dc.contributor.author	Petrucci, J.	-
dc.contributor.author	Berli, M.	-
dc.contributor.author	Budassi, N.	-
dc.contributor.author	Valle, M.	-
dc.contributor.author	Bustamante Labarta, G.	-
dc.contributor.author	Saravia, M.	-
dc.contributor.author	Caccavo, A.	-
dc.contributor.author	Fracaro, V.	-
dc.contributor.author	Cartasegna, L.	-
dc.contributor.author	Novas, V.	-
dc.contributor.author	Caruso, O.	-
dc.contributor.author	Saa Zarandon, R.	-
dc.contributor.author	Colombo, H.	-
dc.contributor.author	Morandini, M.	-
dc.contributor.author	Cuello, J.	-
dc.contributor.author	Rosell, M.	-
dc.contributor.author	Cuneo, C.	-
dc.contributor.author	Bocanera, M.	-
dc.contributor.author	D'Amico, A.	-
dc.contributor.author	Cendali, G.	-
dc.contributor.author	Dran, R.	-
dc.contributor.author	Moreno, V.	-
dc.contributor.author	Estol, C.	-
dc.contributor.author	Davolos, M.	-
dc.contributor.author	Facello, A.	-
dc.contributor.author	Facello, M.	-
dc.contributor.author	Falu, E.	-
dc.contributor.author	Iriarte, M.	-
dc.contributor.author	Femenia, F.	-
dc.contributor.author	Arrieta, M.	-
dc.contributor.author	Fuselli, J.	-
dc.contributor.author	Zanotti, A.	-
dc.contributor.author	Gant Lopez, J.	-
dc.contributor.author	Meiller, F.	-
dc.contributor.author	Garcia Duran, R.	-
dc.contributor.author	Perlo, D.	-
dc.contributor.author	Garrido, M.	-
dc.contributor.author	Ceirano, C.	-
dc.contributor.author	Giacomi, G.	-
dc.contributor.author	Eden, M.	-
dc.contributor.author	Giannaula, R.	-
dc.contributor.author	Huerta, M.	-
dc.contributor.author	Goicoechea, R.	-
dc.contributor.author	von Wulffen, M.	-
dc.contributor.author	Hominal, M.	-
dc.contributor.author	Bianchini, M.	-
dc.contributor.author	Jure, H.	-
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dc.contributor.author	Saravia Toledo, S.	-
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dc.contributor.author	Schmidberg, J.	-
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dc.contributor.author	Arstall, M.	-
dc.contributor.author	Hoffmann, B.	-
dc.contributor.author	Colquhoun, D.	-
dc.contributor.author	Price-Smith, S.	-
dc.contributor.author	Crimmins, D.	-
dc.contributor.author	Slattery, A.	-
dc.contributor.author	Dart, A.	-
dc.contributor.author	Kay, S.	-
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dc.contributor.author	Silver, G.	-
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dc.contributor.author	Gates, P.	-
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dc.contributor.author	Lehman, R.	-
dc.contributor.author	Morrison, H.	-
dc.contributor.author	McKeirnan, M.	-
dc.contributor.author	Li, J.	-
dc.contributor.author	Paul, V.	-
dc.contributor.author	Batta, C.	-
dc.contributor.author	Purnell, P.	-
dc.contributor.author	Perrett, L.	-
dc.contributor.author	Szto, G.	-
dc.contributor.author	O'Shea, V.	-
dc.contributor.author	Capiau, L.	-
dc.contributor.author	Banaeian, F.	-
dc.contributor.author	De Bleecker, J.	-
dc.contributor.author	de Koning, K.	-
dc.contributor.author	De Tollenaere, M.	-
dc.contributor.author	De Bruyne, L.	-
dc.contributor.author	Desfontaines, P.	-
dc.contributor.author	Tincani, G.	-
dc.contributor.author	Heidbuchel, H.	-
dc.contributor.author	Meeusen, K.	-
dc.contributor.author	Herzet, J.	-
dc.contributor.author	Malmendier, D.	-
dc.contributor.author	Mairesse, G.	-
dc.contributor.author	Raepers, M.	-
dc.contributor.author	Parque, J.	-
dc.contributor.author	Clinckemaille, N.	-
dc.contributor.author	Scavee, C.	-
dc.contributor.author	Huyberechts, D.	-
dc.contributor.author	Stockman, D.	-
dc.contributor.author	Jacobs, C.	-
dc.contributor.author	Vandekerckhove, Y.	-
dc.contributor.author	Derycker, K.	-
dc.contributor.author	Vanwelden, J.	-
dc.contributor.author	van Welden, J.	-
dc.contributor.author	Vervoort, G.	-
dc.contributor.author	Mestdagh, I.	-
dc.contributor.author	Vrolix, M.	-
dc.contributor.author	Beerts, C.	-
dc.contributor.author	Wollaert, B.	-
dc.contributor.author	Denie, D.	-
dc.contributor.author	Vincenzo de Paola, A. Amato	-
dc.contributor.author	Coutinho, E.	-
dc.contributor.author	Lotufo, P. Andrade	-
dc.contributor.author	de Melo, R. Ferreira	-
dc.contributor.author	Atie, J.	-
dc.contributor.author	Motta, C.	-
dc.contributor.author	Alves da Costa, F. Augusto	-
dc.contributor.author	Ferraz, R. Franchin	-
dc.contributor.author	Precoma, D. Bertolim	-
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dc.contributor.author	Pozuelos, J. Mayen	-
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dc.contributor.author	de Groot, J.	-
dc.contributor.author	Radder, I.	-
dc.contributor.author	de Vos, R.	-
dc.contributor.author	Hazeleger, R.	-
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dc.contributor.author	Mannaerts, H.	-
dc.contributor.author	Kooiman, E.	-
dc.contributor.author	Mevissen, H.	-
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dc.contributor.author	Anscombe, R.	-
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dc.contributor.author	Fisher, R.	-
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dc.contributor.author	Scott, D.	-
dc.contributor.author	Cammell, R.	-
dc.contributor.author	Troughton, R.	-
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dc.contributor.author	Kang, D. H.	-
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dc.contributor.author	Kim, J. T.	-
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dc.date.available	2021-04-09T07:41:38Z	-
dc.date.issued	2016-08	-
dc.identifier.issn	0039-2499	-
dc.identifier.issn	1524-4628	-
dc.identifier.uri	https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52274	-
dc.description.abstract	Background and Purpose— Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA. Methods— ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind trial of 21 105 patients with atrial fibrillation randomized to warfarin (international normalized ratio, 2.0–3.0; median time-in-therapeutic range, 68.4%) versus once-daily edoxaban (higher-dose edoxaban regimen [HDER], 60/30 mg; lower-dose edoxaban regimen, 30/15 mg) with 2.8-year median follow-up. Primary end points included all stroke/systemic embolic events (efficacy) and major bleeding (safety). Because only HDER is approved, we focused on the comparison of HDER versus warfarin. Results— Of 5973 (28.3%) patients with previous IS/TIA, 67% had CHADS2 (congestive heart failure, hypertension, age, diabetes, prior stroke/transient ischemic attack) >3 and 36% were ≥75 years. Compared with 15 132 without previous IS/TIA, patients with previous IS/TIA were at higher risk of both thromboembolism and bleeding (stroke/systemic embolic events 2.83% versus 1.42% per year; P<0.001; major bleeding 3.03% versus 2.64% per year; P<0.001; intracranial hemorrhage, 0.70% versus 0.40% per year; P<0.001). Among patients with previous IS/TIA, annualized intracranial hemorrhage rates were lower with HDER than with warfarin (0.62% versus 1.09%; absolute risk difference, 47 [8–85] per 10 000 patient-years; hazard ratio, 0.57; 95% confidence interval, 0.36–0.92; P=0.02). No treatment subgroup interactions were found for primary efficacy (P=0.86) or for intracranial hemorrhage (P=0.28). Conclusions— Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00781391.	-
dc.format.extent	8	-
dc.language	영어	-
dc.language.iso	ENG	-
dc.publisher	Lippincott Williams & Wilkins Ltd.	-
dc.title	Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)	-
dc.type	Article	-
dc.publisher.location	미국	-
dc.identifier.doi	10.1161/STROKEAHA.116.013540	-
dc.identifier.scopusid	2-s2.0-84978153834	-
dc.identifier.wosid	000380808400028	-
dc.identifier.bibliographicCitation	Stroke, v.47, no.8, pp 2075 - 2082	-
dc.citation.title	Stroke	-
dc.citation.volume	47	-
dc.citation.number	8	-
dc.citation.startPage	2075	-
dc.citation.endPage	2082	-
dc.type.docType	Article	-
dc.description.isOpenAccess	N	-
dc.description.journalRegisteredClass	sci	-
dc.description.journalRegisteredClass	scie	-
dc.description.journalRegisteredClass	scopus	-
dc.relation.journalResearchArea	Neurosciences & Neurology	-
dc.relation.journalResearchArea	Cardiovascular System & Cardiology	-
dc.relation.journalWebOfScienceCategory	Clinical Neurology	-
dc.relation.journalWebOfScienceCategory	Peripheral Vascular Disease	-
dc.subject.keywordPlus	PREDICTING STROKE	-
dc.subject.keywordPlus	HEMORRHAGE	-
dc.subject.keywordPlus	METAANALYSIS	-
dc.subject.keywordPlus	RIVAROXABAN	-
dc.subject.keywordPlus	PREVENTION	-
dc.subject.keywordAuthor	atrial fibrillation	-
dc.subject.keywordAuthor	clinical trial	-
dc.subject.keywordAuthor	hemorrhage	-
dc.subject.keywordAuthor	risk factors	-
dc.subject.keywordAuthor	stroke	-

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