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Cited 1 time in webofscience Cited 2 time in scopus
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Pain-Relieving Effect of 4.4 MHz of Pulsed Radiofrequency on Acute Knee Arthritis in Rats

Authors
Moon, Sun WookPark, Eui HoPark, Jin SungLee, Seung WonSuh, Hye RimPark, Sang HyunYoon, Seung ZhooPark, Kun WooHan, Hee Chul
Issue Date
Aug-2020
Publisher
Oxford University Press
Keywords
4.4 MHz Pulsed Radiofrequency; Noninvasive; Acute Arthritis; Pain-Related Behavior; Immune Cytokine
Citation
Pain Medicine, v.21, no.8, pp 1572 - 1580
Pages
9
Indexed
SCIE
SCOPUS
Journal Title
Pain Medicine
Volume
21
Number
8
Start Page
1572
End Page
1580
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52309
DOI
10.1093/pm/pnz264
ISSN
1526-2375
1526-4637
Abstract
Objective Drug injections and surgery are popular treatments for knee joint osteoarthritis. However, these treatments are invasive, and new noninvasive treatments with similar or better efficacy are needed. Here, we evaluated the application of 4.4 MHz of pulsed radiofrequency (PRF) as a new treatment. Methods Acute arthritis was induced by injection of carrageenan into the intra-articular space of the knee in male rats. At 4.5 hours after arthritis induction, PRF with the treatment protocol of three seconds on and off was applied to the affected knee joint for 20 minutes. The changes in pain behavior were evaluated by comparing the peak weight load values of both hind paws at pretreatment and four, six, seven, eight, and 24 hours after treatment. And we also used Western blotting and immunohistochemistry to measure the inflammatory changes in the synovial membrane of the inflamed knee. Results We found that the 20-minute application of PRF with the treatment protocol significantly recovered the weight load reduction at six-, seven-, and eight-hour time points after carrageenan injection. COX-2 and IL-1β levels were significantly reduced in the inflamed rats after PRF application at six and eight hours post–carrageenan injection. Immunohistochemistry showed that PRF significantly reduced inflammatory cell infiltration at six hours post–carrageenan injection. Conclusions . Our results indicate that noninvasive PRF application inhibited pain-related behavior and decreased inflammatory cytokine expression in the inflamed knee joints of rats. Accordingly, PRF application can serve as a potential therapeutic treatment to relieve pain associated with peripheral joint/tissue damage or inflammation.
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1. Basic Science > Department of Physiology > 1. Journal Articles
4. Research institute > Institute for Healthcare Service Innovation > 1. Journal Articles
4. Research institute > Center for Good Doctor > 1. Journal Articles
4. Research institute > Neuroscience Research Institute > 1. Journal Articles

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