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Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study

Authors
Yoo, Jeong-JuYoo, Yang JaeMoon, Woo RamKim, Seung UpJeong, Soung WonPark, Ha NaPark, Min GyuJang, Jae YoungPark, Su YeonKim, Beom KyungPark, Jun YongKim, Do YoungAhn, Sang HoonHan, Kwang-HyubKim, Sang GyuneKim, Young SeokKim, Ji HoonYeon, Jong EunByun, Kwan Soo
Issue Date
Nov-2020
Publisher
대한내과학회
Keywords
Fatty liver; Elasticity imaging techniques; Ultrasonography
Citation
The Korean Journal of Internal Medicine, v.35, no.6, pp.1346 - 1353
Indexed
SCIE
KCI
Journal Title
The Korean Journal of Internal Medicine
Volume
35
Number
6
Start Page
1346
End Page
1353
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52355
DOI
10.3904/kjim.2018.309
ISSN
1226-3303
Abstract
Background/Aims: The controlled attenuation parameter (CAP), based on transient elastography, is widely used for noninvasive assessment of the degree of hepatic steatosis (HS). We investigated the correlation of the degree HS between CAP and ultrasound (US) in patients with HS. Methods: In total, 986 patients with US-based HS who underwent transient elastography within 1 month were evaluated. The US-based grade of HS was categorized as mild (grade 1), moderate (grade 2), or severe (grade 3). Results: The CAP was significantly correlated with the US-based grade of HS (r = 0.458, p < 0001). The median CAP value of each US-based HS grade showed a positive correlation with grade (271.1, 303.7, and 326.7 dB/m for grades 1, a, and 3). In a multivariate analysis, the US-based HS grade, body mass index, serum albumin, alanine aminotransferase, and total cholesterol, and liver stiffness were all significantly correlated with the CAP value (all p < 0.05). The areas under the receiver operating characteristic curves for grade a to 3 and grade 3 HS were 0.749 (95% confidence interval [CI], 0.714 to 0.784) and 0.738 (95% CI, 0.704 to 0.772). The optimal cut-off CAP values to maximize the sum of the sensitivity and specificity for grade 2 to 3 and grade 3 HS were 284.5 dB/m (sensitivity 78.6%, specificity 61.7%) and 298.5 dB/m (sensitivity 84.6%, specificity 55.6%). Conclusions: The correlation of the degree of HS between CAP and US was significantly high in patients with HS, and the optimal cut-off CAP values for grade 2 to 3 and grade 3 HS were 284.5 and 298.5 dB/m.
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Byun, Kwan Soo
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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