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Cited 34 time in webofscience Cited 39 time in scopus
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Local Gyrification Index in Patients with Major Depressive Disorder and its Association with Tryptophan Hydroxylase-2 (TPH2) Polymorphism

Authors
Han, Kyu-ManWon, EunsooKang, JuneKim, AramYoon, Ho-KyoungChang, Hun SooSon, Kyu RiLee, Min-SooTae, Woo-SukHam, Byung-Joo
Issue Date
Mar-2017
Publisher
WILEY
Keywords
TPH2 rs4570625; local gyrification index; major depressive disorder; prefrontal cortex; anterior cingulate cortex; orbitofrontal cortex
Citation
HUMAN BRAIN MAPPING, v.38, no.3, pp 1299 - 1310
Pages
12
Indexed
SCI
SCIE
SCOPUS
Journal Title
HUMAN BRAIN MAPPING
Volume
38
Number
3
Start Page
1299
End Page
1310
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5236
DOI
10.1002/hbm.23455
ISSN
1065-9471
1097-0193
Abstract
The tryptophan hydroxylase-2 (TPH2) gene is considered a promising genetic candidate regarding its association with a predisposition to major depressive disorder (MDD). Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. They aimed to investigate the alterations in the cortical gyrification of the prefrontal cortex and anterior cingulate cortex and their association with the TPH2 rs4570625 polymorphism in patients with MDD. One hundred and thirteen patients with MDD and eighty-six healthy controls underwent T1-weighted structural magnetic resonance imaging and genotyping for TPH2 rs4570625. The local gyrification index of 22 cortical regions in the prefrontal cortex and anterior cingulate cortex was analyzed using the FreeSurfer. The patients with MDD showed significant hypergyria in the right rostral anterior cingulate cortex (P50.001), medial orbitofrontal cortex (P50.003), and frontal pole (P50.001). There was a significant genotype-by-diagnosis interaction for the local gyrification index in the right rostral anterior cingulate cortex (P50.003). Their study revealed significant hypergyria of the anterior cingulate cortex and prefrontal cortex and an interactive effect between the diagnosis of MDD and the genotype in the anterior cingulate cortex. This might be associated with the dysfunction of neural circuits mediating emotion processing, which could contribute to pathophysiology of MDD. (C) 2016 Wiley Periodicals, Inc.
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4. Research institute > Brain Convergence Research Center > 1. Journal Articles
2. Clinical Science > Department of Psychiatry > 1. Journal Articles

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Ham, Byung Joo
Anam Hospital (Department of Psychiatry, Anam Hospital)
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