Rapid Alanine Aminotransferase Normalization with Entecavir and Hepatocellular Carcinoma in Hepatitis B Virus-Associated Cirrhosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Eui Joo | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Kwon, Oh Sang | - |
dc.contributor.author | Lee, Heon Nam | - |
dc.contributor.author | Shin, Seung Kak | - |
dc.contributor.author | Kang, Seong Hee | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.contributor.author | Kim, Jeong Han | - |
dc.contributor.author | Kwon, So Young | - |
dc.contributor.author | Suh, Sang Jun | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Kim, Yun Soo | - |
dc.contributor.author | Kim, Ju Hyun | - |
dc.date.available | 2020-11-02T08:50:50Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5242 | - |
dc.description.abstract | Background Sustained abnormal serum alanine aminotransferase (ALT) levels can increase the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B. Aim This study is aimed to confirm the impact of rapid ALT normalization (≤30 IU/L) on HCC risk in patients with hepatitis B virus (HBV)-associated cirrhosis after entecavir (ETV) commencement. Methods A total of 578 treatment-naïve patients with HBV-associated cirrhosis (mean age 51 ± 9 years, male sex 63.3%) were treated with ETV for more than 1 year. Serum ALT and HBV DNA levels were measured at three time points (baseline, 6, and 12 months after ETV commencement) and subjected to risk factor analysis. Results Median follow-up after ETV commencement was 43 (12–98) months. Cumulative incidences of HCC at 1, 3, 5, and 7 years were 0.3, 8.5, 19.5, and 30.6%, respectively. Univariate Cox regression analysis showed that older age, abnormal ALT at 6 months or 12 months, and lower platelet count were significant risk factors for HCC. However, gender, HBeAg positivity, abnormal ALT levels or HBV DNA levels at baseline, and detectable HBV DNA at 6 or 12 months were not risk factors. Multivariate analysis showed that older age (P < 0.001), abnormal ALT at 12 months (P = 0.006), and lower platelet count (P = 0.034) were the risk factors for HCC. Conclusions Abnormal serum ALT levels after ETV commencement are significant risk factor for HCC. Therefore, ALT should be rapidly normalized to minimize the risk of HCC development in patients with HBV-associated cirrhosis. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.title | Rapid Alanine Aminotransferase Normalization with Entecavir and Hepatocellular Carcinoma in Hepatitis B Virus-Associated Cirrhosis | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s10620-016-4431-8 | - |
dc.identifier.scopusid | 2-s2.0-85007460049 | - |
dc.identifier.wosid | 000394974900033 | - |
dc.identifier.bibliographicCitation | Digestive Diseases and Sciences, v.62, no.3, pp 808 - 816 | - |
dc.citation.title | Digestive Diseases and Sciences | - |
dc.citation.volume | 62 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 808 | - |
dc.citation.endPage | 816 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | SERUM ALANINE | - |
dc.subject.keywordPlus | ASPARTATE-AMINOTRANSFERASE | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | DNA LEVEL | - |
dc.subject.keywordPlus | LAMIVUDINE | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | GENOTYPE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordAuthor | Hepatitis B virus | - |
dc.subject.keywordAuthor | Entecavir | - |
dc.subject.keywordAuthor | Alanine aminotransferase | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Cirrhosis | - |
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