Serum interferon-gamma and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy
- Authors
- Han, Sang Youb; Jeong, Kyung Hwan; Ihm, Chun-Gyoo; Kang, Young Sun; Cha, Dae Ryong
- Issue Date
- Mar-2021
- Publisher
- KOREAN SOC NEPHROLOGY
- Keywords
- Chemokine CCL2; IGA glomerulonephritis; Interferons; T helper 1 cells; T helper 2 cells
- Citation
- KIDNEY RESEARCH AND CLINICAL PRACTICE, v.40, no.1, pp 69 - 76
- Pages
- 8
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KIDNEY RESEARCH AND CLINICAL PRACTICE
- Volume
- 40
- Number
- 1
- Start Page
- 69
- End Page
- 76
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52557
- DOI
- 10.23876/j.krcp.20.157
- ISSN
- 2211-9132
2211-9140
- Abstract
- Background: Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropathy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. Methods: Thirty-one patients with biopsy-proven IgAN (age, 34.48 +/- 12.10 years) and 25 healthy controls (age, 44.84 +/- 13.72 years) were enrolled. We evaluated the relationship between the levels of Th1/Th2 cytokines and the response to glucocorticoid treatment. Results: The levels of serum interferon-gamma (IFN gamma) and urinary monocyte chemoattractant peptide (MCP)-1 were higher in the IgAN group than in the control group. The levels of MCP-1 in urine and secreted by peripheral blood mononuclear cells (PBMCs) were significantly different among three groups categorized based on daily proteinuria. The level of urinary MCP-1 was significantly correlated with proteinuria. The levels of urinary MCP-1, serum interleukin (IL)-4, IFN gamma, and IL-2 secreted by PBMCs and intrarenal IL-1 messenger RNA (mRNA) were significantly correlated with the ratio of proteinuria at 6 months to baseline proteinuria in patients undergoing glucocorticoid treatment. MCP-1 mRNA and protein levels were significantly upregulated in mesangial cells stimulated with IFN gamma among representative Th1/Th2 cytokines. Conclusion: IFN gamma was shown to be a key cytokine in the pathogenic processes underlying IgAN, and its upregulation induced an increase in urinary MCP-1 production. These findings suggest that Th1 cytokines may play an important role in the development of IgAN.
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Collections - 2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
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