Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Biologic therapies for the treatment of rheumatoid arthritis

Authors
Choi, Sung-Jae
Issue Date
Feb-2021
Publisher
대한의사협회
Keywords
Rheumatoid arthritis; Treatment; Biological products; Antirheumatic drugs
Citation
Journal of the Korean Medical Association, v.64, no.2, pp 95 - 104
Pages
10
Indexed
SCOPUS
ESCI
KCI
Journal Title
Journal of the Korean Medical Association
Volume
64
Number
2
Start Page
95
End Page
104
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52656
DOI
10.5124/jkma.2021.64.2.95
ISSN
1975-8456
2093-5951
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the synovial joints. If left untreated, persistent synovial inflammation can lead to cartilage and bone destruction, ultimately causing significant long-term disability and mortality. However, since the late 1990s, the combined use of methotrexate, a synthetic disease-modifying antirheumatic drug (DMARD), and a biological DMARD has revolutionized the treatment of RA. As of 2021, the Korea Food and Drug Administration has approved seven biological DMARDs for RA treatment: four tumor necrosis factor-alpha inhibitors (infliximab, etanercept, adalimumab, and golimumab) and three non-tumor necrosis factor biological products (abatacept, rituximab, and tocilizumab). Although the use of biological products has allowed significant advances in the treatment of RA, there are certain drawbacks, such as high cost, increased infection risk, and the necessity for parenteral route product administration. Therefore, discontinuation of biological DMARD use without a resulting disease flare is the next treatment goal and a desirable result from the standpoint of risk reduction and cost-effectiveness, especially for patients with clinical remission. It is still unclear which biological product is the best. Clinicians must, therefore, personalize the sequence and strategy of treatment by considering patient characteristics, disease activity, comorbidity, and economic condition
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Rheumatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE