Association between vascular inflammation and non-alcoholic fatty liver disease: Analysis by F-18-fluorodeoxyglucose positron emission tomography
- Authors
- Lee, Hyun Jung; Lee, Chang Hee; Kim, Sungeun; Hwang, Soon Young; Hong, Ho Cheol; Choi, Hae Yoon; Chung, Hye Soo; Yoo, Hye Jin; Seo, Ji A.; Kim, Sin Gon; Kim, Nan Hee; Balk, Sei Hyun; Choi, Dong Seop; Choi, Kyung Mook
- Issue Date
- Feb-2017
- Publisher
- Elsevier BV
- Keywords
- Nonalcoholic fatty liver disease; Inflammation; Positron emission tomography
- Citation
- Metabolism: Clinical and Experimental, v.67, pp 72 - 79
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Metabolism: Clinical and Experimental
- Volume
- 67
- Start Page
- 72
- End Page
- 79
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5286
- DOI
- 10.1016/j.metabol.2016.11.004
- ISSN
- 0026-0495
1532-8600
- Abstract
- Background. Growing evidence suggests that non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease as well as metabolic syndrome. FDG-PET is a novel imaging technique that detects vascular inflammation, which may reflect rupture-prone vulnerable atherosclerotic plaques. Methods. Vascular inflammation was measured as the maximum target-to-background ratio (maxTBR), along with various cardiometabolic risk factors in 51 subjects with NAFLD, and compared with 100 age- and gender-matched subjects without NAFLD. The liver attenuation index (LAI), which was measured using computed tomography, was used as a parameter for the diagnosis of NAFLD. Results. After adjusting for age and sex, both maxTBR and LAI values were associated with several cardiometabolic risk parameters. Furthermore, there was a significant interrelationship between LAI and maxTBR values (r = 0.227, P = 0.005). Individuals with NAFLD had higher maxTBR values than those without NAFLD (P = 0.026), although their carotid intima media thickness (CIMT) values did not differ. The proportion of subjects with NAFLD showed a step-wise increment following the tertiles of maxTBR values (P for trend = 0.015). In multiple logistic regression analysis, maxTBR tertiles were independently associated with NAFLD after adjusting for age, gender, systolic blood pressure, triglycerides, HDL-cholesterol, glucose, BUN, creatinine and homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.030). However, their relationship was attenuated after further adjustment for waist circumference or high sensitive C-reactive protein. Conclusion. Patients with NAFLD have an increased risk for vascular inflammation as measured via FDG-PET/CT even without difference in CIMT. (C) 2016 Elsevier Inc. All rights reserved.
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