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Cited 4 time in webofscience Cited 10 time in scopus
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Predictive Value of Radiologic Central Compartment Atopic Disease for Identifying Allergy and Asthma in Pediatric Patients

Authors
Lee, KijeongKim, Tae HoonLee, Sang HagKang, Chang HoJe, Bo-KyungOh, Saelin
Issue Date
Nov-2022
Publisher
SAGE Publications Ltd
Keywords
allergy; central compartment atopic disease; chronic rhinosinusitis; computed tomography; pediatrics
Citation
Ear, Nose and Throat Journal, v.101, no.9, pp 593 - 599
Pages
7
Indexed
SCIE
SCOPUS
Journal Title
Ear, Nose and Throat Journal
Volume
101
Number
9
Start Page
593
End Page
599
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/52935
DOI
10.1177/0145561321997546
ISSN
0145-5613
1942-7522
Abstract
Introduction: Central compartment atopic disease (CCAD) has recently been suggested as a phenotype of chronic rhinosinusitis (CRS). This study aims to investigate the prevalence of the radiologic CCAD phenotype in CRS within a pediatric population and identify its ability to predict comorbid allergy and asthma. Methods: Computed tomography and endoscopic examination were conducted on pediatric patients with CRS either with or without nasal polyps. Allergen sensitization was determined with the multiple-allergen simultaneous test and skin prick test. Serum total immunoglobulin E (IgE), peripheral blood eosinophil percentage, and presence of asthma were also evaluated. Results: A total of 82 pediatric patients were enrolled. Overall, 55 (67.1%) of the participants demonstrated aeroallergen sensitization, and 31 (18.9%) of the 164 sides of sinuses were radiologically defined to fit the CCAD phenotype. Patients having CRS with the CCAD phenotype had a higher prevalence of aeroallergen sensitization (87.1% vs 62.4%, P = .008), particularly house dust mite (74.2% vs 53.4%, P = .035), and a higher incidence of asthma (16.1% vs 3.8%, P = .010). Additionally, patients having CRS with the CCAD phenotype demonstrated a high serum total IgE levels (51.6% vs 30.1%, P = .023) in comparison to patients having CRS without CCAD. Conclusion: In pediatric CRS, the radiological CCAD phenotype was associated with allergen sensitization and asthma. Furthermore, the CCAD phenotype was associated with high serum total IgE levels, suggesting allergy etiology should be considered with this type of pediatric patients with CRS.
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2. Clinical Science > Department of Radiology > 1. Journal Articles
2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles

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Lee, Sang Hag
Anam Hospital (Department of Otorhinolaryngology-Head and Neck Surgery, Anam Hospital)
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