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Cited 34 time in webofscience Cited 33 time in scopus
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An Explorative Analysis for the Role of Serum miR-10b-3p Levels in Predicting Response to Sorafenib in Patients with Advanced Hepatocellular Carcinoma

Authors
Yoon, Eileen L.Yeon, Jong EunKo, EunjungLee, Hyun JungJe, Ji HyeYoo, Yang JaeKang, Seong HeeSuh, Sang JunKim, Ji HoonSeo, Yeon SeokYim, Hyung JoonByun, Kwan Soo
Issue Date
Feb-2017
Publisher
대한의학회
Keywords
Serum MicroRNA; Hepatocellular Carcinoma; Sorafenib; Survival; Macrovascular Invasion
Citation
Journal of Korean Medical Science, v.32, no.2, pp 212 - 220
Pages
9
Indexed
SCI
SCIE
SCOPUS
KCI
Journal Title
Journal of Korean Medical Science
Volume
32
Number
2
Start Page
212
End Page
220
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5295
DOI
10.3346/jkms.2017.32.2.212
ISSN
1011-8934
1598-6357
Abstract
The prognostic role of aberrant serum miRNA expression for predicting response to sorafenib treatment in advanced hepatocellular carcinoma (HCC) patients has not been well characterized. We aimed to identify specific serum miRNAs that are associated with positive radiologic responses or improved survival in sorafenib-treated HCC patients. miR-18a, miR-21, miR-139-5p, miR-221, miR-224, and miR-10b-3p, were selected for analysis. Serum samples from 24 patients with advanced stage HCC and 25 patients with liver cirrhosis (LC) were analyzed. All of the miRNAs except miR-21 were found to be upregulated in serum samples from HCC patients. None of the miRNAs assayed differed significantly in terms of expression between the responder and non-responder groups among HCC patients. However, miR-10b-3p levels were significantly higher in the subgroup of HCC patients with worse overall survival (fold change = 5.8, P = 0.008). Serum miRNA-10b-3p was upregulated in the presence of macrovascular invasion (MVI), and those with higher serum miRNA-10b-3p had significantly shorter survival during treatment (P = 0.042). Although no single serum miRNA was predictive of response to sorafenib treatment, analysis of serum miR-10b-3p levels may be valuable for diagnosis of HCC and prediction of survival of sorafenib-treated patients.
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Kim, Ji Hoon
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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