Detailed Information

Cited 4 time in webofscience Cited 4 time in scopus
Metadata Downloads

Clinical Implication of Liquid Biopsy in Colorectal Cancer Patients Treated with Metastasectomy

Authors
Lee, SoohyeonPark, Young-SooChang, Won-JinChoi, Jung YoonLim, AhreumKim, BoyeonLee, Sat ByolLee, Jong-WonKim, Seon-HahnKim, JinKwak, Jung-MyunYoon, Kyung-ChulLee, Sung-HoKim, Yeul Hong
Issue Date
May-2021
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
circulating tumor DNA; liquid biopsy; metastatic colorectal cancer; metastasectomy
Citation
Cancers, v.13, no.9
Indexed
SCIE
SCOPUS
Journal Title
Cancers
Volume
13
Number
9
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53071
DOI
10.3390/cancers13092231
ISSN
2072-6694
Abstract
Simple Summary Circulating tumor DNA (ctDNA) is tumor-derived fragmented DNA in the bloodstream that was shed from primary and/or metastatic tumors. ctDNA in patients with oligometastatic colorectal cancer (CRC) was detected before and after metastasectomy depending on the clinical context. The detection rate of ctDNA was higher in liver metastasis than lung metastasis and tumors measuring >= 1 cm and small tumors <1 cm. After metastasectomy for oligometastatic lesions with good response to neoadjuvant chemotherapy, most ctDNA was cleared or existed below the detection level. Biological characteristics affecting tumor DNA release should be considered when applying ctDNA assays in clinical settings. Background & Aims: The application of circulating tumor DNA (ctDNA) has been studied for predicting recurrent disease after surgery and treatment response during systemic treatment. Metastasectomy can be curative for well-selected patients with metastatic colorectal cancer (mCRC). This prospective study investigated the ctDNA level before and after metastasectomy in patients with mCRC to explore its potential as a predictive biomarker. Methods: We collected data on 98 metastasectomies for mCRC performed from March 2017 to February 2020. Somatic mutations in the primary and metastatic tumors were identified and tumor-informed ctDNAs were selected by ultra-deep targeted sequencing. Plasma samples were mandatorily collected before and 3-4 weeks after metastasectomy and serially, if patients agreed. Results: Data on 67 of 98 metastasectomies (58 patients) meeting the criteria were collected. ctDNA was detected in 9 (29%) of 31 cases treated with upfront metastasectomy and in 7 (19.4%) of 36 cases treated with metastasectomy after upfront chemotherapy. The detection rate of ctDNA was higher in liver metastasis (p = 0.0045) and tumors measuring >= 1 cm (p = 0.0183). ctDNA was less likely to be detected if the response to chemotherapy was good. After metastasectomy, ctDNA was found in 4 (6%) cases with rapid progressive disease. Conclusion: The biological factors affecting the ctDNA shedding from the tumor should be considered when applying ctDNA assays in a clinical setting. After metastasectomy for oligometastatic lesions in good responders of chemotherapy, most ctDNA was cleared or existed below the detection level. To assist clinical decision making after metastasectomy for mCRC using ctDNA, further studies for improving specific outcomes are needed.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Thoracic and Cardiovascular Surgery > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
4. Research institute > Cancer Institute > 1. Journal Articles
2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Yeul Hong photo

Kim, Yeul Hong
안암병원 (Department of Medical Oncology and Hematology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE