Detailed Information

Cited 1 time in webofscience Cited 3 time in scopus
Metadata Downloads

Novel Ablation Therapy Using Endoscopic Irreversible Electroporation in the Bile Duct: A Pilot Animal StudyNovel Ablation Therapy Using Endoscopic Irreversible Electroporation in the Bile Duct: A Pilot Animal Study

Other Titles
Novel Ablation Therapy Using Endoscopic Irreversible Electroporation in the Bile Duct: A Pilot Animal Study
Authors
Kang Won LeeJae Min LeeHyuk Soon ChoiEun Sun KimBora KeumYeon Seok SeoYoon Tae JeenSoon Ho UmHong Sik LeeHoon Jai ChunChang Duck KimChi Hyuk OhHong Bae Kim
Issue Date
May-2021
Publisher
대한소화기내시경학회
Keywords
Ablation; Bile duct; Endoscopic retrograde cholangiopancreatography; Irreversible electroporation
Citation
Clinical Endoscopy, v.54, no.3, pp.413 - 419
Indexed
SCOPUS
KCI
Journal Title
Clinical Endoscopy
Volume
54
Number
3
Start Page
413
End Page
419
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53146
DOI
10.5946/ce.2020.126
ISSN
2234-2400
Abstract
Background/Aims: Irreversible electroporation (IRE) is a relatively new ablation method. However, the application of IREablation in the treatment of biliary disease has not been attempted. A minimally invasive approach using endoscopic retrogradecholangiopancreatography (ERCP) can be a novel therapeutic modality for IRE ablation. In this study, we aimed to investigate thefeasibility of endoscopic IRE for the biliary tract using an animal model. Methods: A new catheter-type electrode was developed for endoscopic IRE ablation of the biliary tract. We performed ERCP andendoscopic IRE ablations in the normal common bile duct of Yorkshire pigs. The experimental setting of IRE was 500 V/cm (50pulses, 100-μs length). The animals were sacrificed after 24 hr, and the ablated bile duct was examined. Results: Well-demarcated focal color changes were observed on the mucosa of the common bile duct. The depth of change after IREwas confined to the mucosal and submucosal layers. Apoptotic changes in the bile duct were observed only around the IRE ablationarea. Immunohistochemistry assay showed cell death in the bile duct along the electrode. Conclusions: Endoscopic IRE ablation using ERCP was successfully performed in the common bile duct. It can be a potential optionfor the treatment of biliary tumors.
Files in This Item
There are no files associated with this item.
Appears in
Collections
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Seo, Yeon Seok photo

Seo, Yeon Seok
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE