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Cited 3 time in webofscience Cited 2 time in scopus
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Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma

Authors
Lee, Han AhLee, Young-SunKim, Beom KyungJung, Young KulKim, Seung UpPark, Jun YongKim, Ji HoonAn, HyungginKim, Do YoungYim, Hyung JoonAhn, Sang HoonYeon, Jong EunByun, Kwan SooHan, Kwang-HyubUm, Soon HoSeo, Yeon Seok
Issue Date
May-2021
Publisher
거트앤리버 발행위원회
Keywords
Recurrence; Risk factor; Barcelona Clinic Liver Cancer stage A; Carcinoma, hepatocellular
Citation
Gut and Liver, v.15, no.3, pp.420 - 429
Indexed
SCIE
SCOPUS
KCI
Journal Title
Gut and Liver
Volume
15
Number
3
Start Page
420
End Page
429
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53244
DOI
10.5009/gnl20101
ISSN
1976-2283
Abstract
Background/Aims: We investigated changes in recurrence rates and significant recurrence predictors over time after complete cure of hepatocellular carcinoma (HCC). Methods: A total of 1,491 patients with first-time diagnosis of Barcelona Clinic Liver Cancer stage A HCC, completely cured by treatment between 2007 and 2016, were recruited from two Korean tertiary institutes. Results: The mean age of the population (1,144 men and 347 women) was 58.6 years. Of the total population, 914 patients (61.3%) had liver cirrhosis. Nine-hundred and forty-one (63.1%) and 550 (36.9%) patients were treated with surgical resection and radiofrequency ablation (RFA), respectively. One-year cumulative incidences of HCC recurrence were 14.3%, 9.9%, and 5.1% from the time of treatment, 3 years after treatment, and 5 years after treatment, respectively. Upon multivariate analysis, multiple tumors, maximal tumor size ≥3 cm, and high Model for End-Stage Liver Disease scores were independently associated with increased HCC recurrence risk from the time of treatment and 1 and 2 years after curative treatment (all p<0.05, except for maximal tumor size ≥3 cm for recurrence 2 years after treatment). Meanwhile, liver cirrhosis and RFA were independently associated with the increased HCC recurrence risk for almost all time points (liver cirrhosis: all p<0.05; RFA: all p<0.005 except for recurrence from 5 years after treatment). Conclusions: The recurrence rate of HCC after curative treatment gradually decreased over time. Two years after treatment, when tumor-related factors lose their prognostic implications, may be used as a cutoff to define the boundary between early and late recurrence of HCC.
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1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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