Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Han Ah | - |
dc.contributor.author | Lee, Young-Sun | - |
dc.contributor.author | Kim, Beom Kyung | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Kim, Seung Up | - |
dc.contributor.author | Park, Jun Yong | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | An, Hyunggin | - |
dc.contributor.author | Kim, Do Young | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Ahn, Sang Hoon | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.contributor.author | Han, Kwang-Hyub | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.date.accessioned | 2021-06-23T05:40:15Z | - |
dc.date.available | 2021-06-23T05:40:15Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53244 | - |
dc.description.abstract | Background/Aims: We investigated changes in recurrence rates and significant recurrence predictors over time after complete cure of hepatocellular carcinoma (HCC). Methods: A total of 1,491 patients with first-time diagnosis of Barcelona Clinic Liver Cancer stage A HCC, completely cured by treatment between 2007 and 2016, were recruited from two Korean tertiary institutes. Results: The mean age of the population (1,144 men and 347 women) was 58.6 years. Of the total population, 914 patients (61.3%) had liver cirrhosis. Nine-hundred and forty-one (63.1%) and 550 (36.9%) patients were treated with surgical resection and radiofrequency ablation (RFA), respectively. One-year cumulative incidences of HCC recurrence were 14.3%, 9.9%, and 5.1% from the time of treatment, 3 years after treatment, and 5 years after treatment, respectively. Upon multivariate analysis, multiple tumors, maximal tumor size ≥3 cm, and high Model for End-Stage Liver Disease scores were independently associated with increased HCC recurrence risk from the time of treatment and 1 and 2 years after curative treatment (all p<0.05, except for maximal tumor size ≥3 cm for recurrence 2 years after treatment). Meanwhile, liver cirrhosis and RFA were independently associated with the increased HCC recurrence risk for almost all time points (liver cirrhosis: all p<0.05; RFA: all p<0.005 except for recurrence from 5 years after treatment). Conclusions: The recurrence rate of HCC after curative treatment gradually decreased over time. Two years after treatment, when tumor-related factors lose their prognostic implications, may be used as a cutoff to define the boundary between early and late recurrence of HCC. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 거트앤리버 발행위원회 | - |
dc.title | Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5009/gnl20101 | - |
dc.identifier.scopusid | 2-s2.0-85106539992 | - |
dc.identifier.wosid | 000652440500012 | - |
dc.identifier.bibliographicCitation | Gut and Liver, v.15, no.3, pp 420 - 429 | - |
dc.citation.title | Gut and Liver | - |
dc.citation.volume | 15 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 420 | - |
dc.citation.endPage | 429 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002716889 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | INTRAHEPATIC RECURRENCE | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordAuthor | Recurrence | - |
dc.subject.keywordAuthor | Risk factor | - |
dc.subject.keywordAuthor | Barcelona Clinic Liver Cancer stage A | - |
dc.subject.keywordAuthor | Carcinoma, hepatocellular | - |
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