A Comparative Study on Aqueous Chitosan Solution and Various Submucosal Injection Fluids Using a Three-Dimensional Sensor
- Jeon, Han Jo; Jeong, Seung; Choi, Hyuk Soon; Jang, Se Hyun; Kim, Sang Hoon; Kim, Seung Han; Lee, Jae Min; Kim, Eun Sun; Keum, Bora; Jeen, Yoon Tae; Lee, Hong Sik; Chun, Hoon Jai; Chung, Jong Hoon; Kim, Seong Nam
- Issue Date
- 거트앤리버 발행위원회
- Endoscopy; gastrointestinal; Chitosan; Stomach; Injections; Imaging; three-dimensional
- Gut and Liver, v.15, no.2, pp.217 - 224
- Journal Title
- Gut and Liver
- Start Page
- End Page
- Background/Aims: Chitosan, a natural polymer widely used in the biomaterials field, has been proposed as a potential submucosal injection solution. The purpose of this study was to compare the performance and efficacy of aqueous chitosan solution and commercialized submucosal injection fluids using a three-dimensional sensor and to evaluate the efficacy of the measured parameters. Methods: Normal saline (0.9% NaCl), as a control, Eleview (R) (Poloxamer 188), Blue Eye (TM) (0.4% hyaluronic acid), and aqueous chitosan solution (2.0%) were injected into the submucosa of porcine stomachs ex vivo. The mucosal elevation height, elevated surface area, and angle of the tangent of the submucosal fluid cushion were measured using a three-dimensional sensor. The rates of change for each variable were calculated, and the correlation between parameters was analyzed. Tissue specimens were stained with hematoxylin and eosin. Results: All variables exhibited the highest values under chitosan injection. The mucosal elevation height rate of change differed significantly between normal saline and chitosan solution (p=0.024). The elevated surface area rates of change for normal saline and Eleview (R) were significantly different from those for TS-905 and chitosan solution (p=0.006 and p=0.009, respectively). Further, height, area, and angle showed a positive correlation (p<0.001). A histological examination revealed an even distribution of aqueous chitosan within the submucosa without tissue damage. Conclusions: Aqueous chitosan was superior to normal saline and Eleview (R) and was noninferior to TS-905. A three-dimensional sensor and the measured parameters were effective and useful for evaluating the performance of submucosal fluids.
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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