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Cited 2 time in webofscience Cited 2 time in scopus
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A Comparative Study on Aqueous Chitosan Solution and Various Submucosal Injection Fluids Using a Three-Dimensional Sensor

Authors
Jeon, Han JoJeong, SeungChoi, Hyuk SoonJang, Se HyunKim, Sang HoonKim, Seung HanLee, Jae MinKim, Eun SunKeum, BoraJeen, Yoon TaeLee, Hong SikChun, Hoon JaiChung, Jong HoonKim, Seong Nam
Issue Date
Mar-2021
Publisher
거트앤리버 발행위원회
Keywords
Endoscopy; gastrointestinal; Chitosan; Stomach; Injections; Imaging; three-dimensional
Citation
Gut and Liver, v.15, no.2, pp.217 - 224
Indexed
SCIE
SCOPUS
KCI
Journal Title
Gut and Liver
Volume
15
Number
2
Start Page
217
End Page
224
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53725
DOI
10.5009/gnl19383
ISSN
1976-2283
Abstract
Background/Aims: Chitosan, a natural polymer widely used in the biomaterials field, has been proposed as a potential submucosal injection solution. The purpose of this study was to compare the performance and efficacy of aqueous chitosan solution and commercialized submucosal injection fluids using a three-dimensional sensor and to evaluate the efficacy of the measured parameters. Methods: Normal saline (0.9% NaCl), as a control, Eleview (R) (Poloxamer 188), Blue Eye (TM) (0.4% hyaluronic acid), and aqueous chitosan solution (2.0%) were injected into the submucosa of porcine stomachs ex vivo. The mucosal elevation height, elevated surface area, and angle of the tangent of the submucosal fluid cushion were measured using a three-dimensional sensor. The rates of change for each variable were calculated, and the correlation between parameters was analyzed. Tissue specimens were stained with hematoxylin and eosin. Results: All variables exhibited the highest values under chitosan injection. The mucosal elevation height rate of change differed significantly between normal saline and chitosan solution (p=0.024). The elevated surface area rates of change for normal saline and Eleview (R) were significantly different from those for TS-905 and chitosan solution (p=0.006 and p=0.009, respectively). Further, height, area, and angle showed a positive correlation (p<0.001). A histological examination revealed an even distribution of aqueous chitosan within the submucosa without tissue damage. Conclusions: Aqueous chitosan was superior to normal saline and Eleview (R) and was noninferior to TS-905. A three-dimensional sensor and the measured parameters were effective and useful for evaluating the performance of submucosal fluids.
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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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