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Cited 2 time in webofscience Cited 2 time in scopus
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Clinical characteristics of patients in their forties who underwent surgical resection for colorectal cancer in Korea

Authors
Lee, Chang SinBaek, Se-JinKwak, Jung-MyunKim, JinKim, Seon-Hahn
Issue Date
7-Jul-2021
Publisher
BAISHIDENG PUBLISHING GROUP INC
Keywords
Colorectal neoplasm; Young age; Hereditary cancer; Sporadic cancer; Screening
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v.27, no.25, pp 3901 - 3912
Pages
12
Indexed
SCIE
SCOPUS
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
Volume
27
Number
25
Start Page
3901
End Page
3912
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53927
DOI
10.3748/wjg.v27.i25.3901
ISSN
1007-9327
2219-2840
Abstract
BACKGROUND The proportion of young patients with colorectal cancer (CRC), especially in their 40s, is increasing worldwide. AIM To confirm the clinical characteristics of such patients, we planned a study comparing them to patients in their 30s and 50s. METHODS Patients undergoing primary resection for CRC, patients in their 30s, 40s and 50s were included in the study. Patient and tumor characteristics, and perioperative and oncologic outcomes were compared. RESULTS Most clinical characteristics of 451 (10.5%) patients in their 40s were more similar to those of patients in their 30s than those in their 50s. On pathology data, there were more metastatic lesions (30s vs 40s vs 50s; 17.5% vs 21.1% vs 14.9%, P = 0.012) in patients in their 40s. There was a trend toward less frequent K-ras mutations among patients in their 40s (48.5% vs 33.3% vs 44.5%, P = 0.064). The proportion of patients receiving postoperative chemotherapy was also significantly greater among patients in their 40s (58.3% vs 63.9% vs 56.3%, P = 0.032). Five-year overall survival (OS) and disease-free survival (DFS) did not differ between the three groups (5-year OS, 92.2% vs 89.8% vs 92.2%, P = 0.804; 5-year total DFS, 98.6% vs 95.7% vs 96.1%, P = 0.754; 5-year local DFS, 98.6% vs 94.3% vs 94.9%, P = 0.579; 5-year systemic DFS, 86.4% vs 87.9 % vs 86.4%, P = 0.908). CONCLUSION Patients with CRC in their 40s showed significantly more numerous metastatic lesions. The oncologic outcome of stage 1-3 patients in their 40s was not inferior compared to that of those in their 30s and 50s.
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Kim, Jin
Anam Hospital (Department of Colon and Rectal Surgery, Anam Hospital)
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