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Serum milk fat globule-EGF factor 8 protein as a potential biomarker for metabolic syndromeopen access

Authors
Lee, Han AhLim, JihwanJoo, Hyung JoonLee, Young-SunJung, Young KulKim, Ji HoonAn, HyungginYim, Hyung JoonJeen, Yoon TaeYeon, Jong EunLim, Do-SunByun, Kwan SooSeo, Yeon Seok
Issue Date
Jul-2021
Publisher
대한간학회
Keywords
Milk fat globule-EGF factor-8; Metabolic syndrome; Biomarkers; Diagnosis
Citation
Clinical and Molecular Hepatology, v.27, no.3, pp.463 - 473
Indexed
SCIE
SCOPUS
KCI
Journal Title
Clinical and Molecular Hepatology
Volume
27
Number
3
Start Page
463
End Page
473
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/53953
DOI
10.3350/cmh.2020.0351
ISSN
2287-2728
Abstract
Background/Aims Useful biomarkers for metabolic syndrome have been insufficient. We investigated the performance of serum milk fat globule-EGF factor-8 (MFG-E8), the key mediator of inflammatory pathway, in diagnosis of metabolic syndrome. Methods Subjects aged between 30 and 64 years were prospectively enrolled in the Seoul Metabolic Syndrome cohort. Serum MFG-E8 levels were measured at baseline. Results A total of 556 subjects were included, comprising 279 women (50.2%) and 277 men (49.8%). Metabolic syndrome was diagnosed in 236 subjects (42.4%), and the mean MFG-E8 level of subjects with metabolic syndrome was significantly higher than that of subjects without metabolic syndrome (P<0.001). MFG-E8 level was significantly correlated with all metabolic syndrome components and pulse wave velocity (all P<0.05). Subjects were categorized into two groups according to the best MFG-E8 cut-off value as follows: group 1, MFG-E8 level <4,745.1 pg/mL (n=401, 72.1%); and group 2, MFG-E8 level ≥4,745.1 (n=155, 27.9%). At baseline, metabolic syndrome in group 2 was significantly more prevalent than in group 1 (63.9% vs. 34.2%, P<0.001). During median follow-up of 17 months, metabolic syndrome developed in 122 (38.1%) subjects among 320 subjects without it at baseline. The incidence of metabolic syndrome in group 2 was significantly higher than that in group 1 (55.4% vs. 34.5%, P=0.003). On multivariate analysis, MFG-E8 level ≥4,745.1 pg/mL was an independent predictor for diagnosis and development of metabolic syndrome after adjusting other factors (all P<0.05). Conclusions Serum MFG-E8 level is a potent biomarker for the screening and prediction of metabolic syndrome.
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1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Cardiology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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