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Cited 3 time in webofscience Cited 2 time in scopus
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The LAW index as an accurate indicator of the initiation of antiviral treatment in patients with chronic hepatitis B

Authors
Lee, Jae MinSeo, Yeon SeokKim, Tae HyungAhn, Jem MaYim, Sun YoungKim, Seung UpJung, Young KulKim, Ji HoonAn, HyungginYim, Hyung JoonYeon, Jong EunLee, Hong SikByun, Kwan SooUm, Soon HoKim, Chang DuckRyu, Ho Sang
Issue Date
Jan-2017
Publisher
Blackwell Publishing Inc.
Keywords
antiviral treatment; APRI; chronic hepatitis B; index; liver stiffness measurement
Citation
Journal of Gastroenterology and Hepatology, v.32, no.1, pp 208 - 214
Pages
7
Indexed
SCI
SCIE
SCOPUS
Journal Title
Journal of Gastroenterology and Hepatology
Volume
32
Number
1
Start Page
208
End Page
214
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5396
DOI
10.1111/jgh.13447
ISSN
0815-9319
1440-1746
Abstract
Background and Aim Considering that inflammation and fibrosis are major factors for the indication of antiviral treatment, liver stiffness measurements could help identify patients who require antiviral treatment. This study evaluated factors that best identify patients who require antiviral treatment and to develop a new indicator for chronic hepatitis B (CHB). Methods Patients with CHB were randomly classified into a training or validation group, and a model for predicting necroinflammatory activity ≥ A3 or fibrosis grade ≥ F2 (A3F2) was established in the training group using binary regression analysis and validated in the validation group. Predictive efficacy was compared using area under the receiver-operating characteristics curve analysis. Results Four-hundred ninety-two patients were enrolled. In the training group, female sex, aspartate aminotransferase-to-platelet count ratio index (APRI), and liver stiffness were independent predictors of A3F2 on multivariate analysis. These variables were used to construct a novel model, called the LAW (liver stiffness, APRI, woman) index, as follows: 1.5 × liver stiffness value (kPa) + 3.9 × APRI + 3.2 if female. The LAW index was a better predictor of A3F2 than the APRI or liver stiffness measurement in both training group (0.870; 95% confidence interval, 0.822–0.910) and validation group (0.862; 95% confidence interval, 0.813–0.903). Conclusions The LAW index was able to accurately identify patients with CHB who required antiviral treatment. A LAW index of >10.1 could be a strong indicator for the initiation of antiviral treatment in patients with CHB.
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Lee, Hong Sik
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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