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Cited 14 time in webofscience Cited 14 time in scopus
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Value of early check-up of carbohydrate antigen 19-9 levels for pancreatic cancer screening in asymptomatic new-onset diabetic patients

Authors
Choe, Jung WanKim, Jae SeonKim, Hyo JungHwang, Soon YoungJoo, Moon KyungLee, Beom JaeKim, Ji HoonYeon, Jong EunPark, Jong JaeByun, Kwan SooBak, Young Tae
Issue Date
May-2016
Publisher
Lippincott Williams & Wilkins Ltd.
Keywords
diabetes mellitus; pancreatic neoplasms; early detection of cancer; CA 19-9 antigen
Citation
Pancreas, v.45, no.5, pp 730 - 734
Pages
5
Indexed
SCI
SCIE
SCOPUS
Journal Title
Pancreas
Volume
45
Number
5
Start Page
730
End Page
734
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54133
DOI
10.1097/MPA.0000000000000538
ISSN
0885-3177
1536-4828
Abstract
Objectives We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients. Methods Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013. Results In total, 2363 asymptomatic diabetic patients with CA 19-9 measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease. Conclusions Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.
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2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Park, Jong Jae
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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