Value of early check-up of carbohydrate antigen 19-9 levels for pancreatic cancer screening in asymptomatic new-onset diabetic patients
- Authors
- Choe, Jung Wan; Kim, Jae Seon; Kim, Hyo Jung; Hwang, Soon Young; Joo, Moon Kyung; Lee, Beom Jae; Kim, Ji Hoon; Yeon, Jong Eun; Park, Jong Jae; Byun, Kwan Soo; Bak, Young Tae
- Issue Date
- May-2016
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- diabetes mellitus; pancreatic neoplasms; early detection of cancer; CA 19-9 antigen
- Citation
- Pancreas, v.45, no.5, pp 730 - 734
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Pancreas
- Volume
- 45
- Number
- 5
- Start Page
- 730
- End Page
- 734
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54133
- DOI
- 10.1097/MPA.0000000000000538
- ISSN
- 0885-3177
1536-4828
- Abstract
- Objectives
We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients.
Methods
Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013.
Results
In total, 2363 asymptomatic diabetic patients with CA 19-9 measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease.
Conclusions
Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 5. Others > Medical Science Research Management Center > 1. Journal Articles
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.