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Cited 13 time in webofscience Cited 14 time in scopus
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Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression

Authors
Lee, Sehe DongChoe, Jung WanLee, Beom JaeKang, Myoung HeeJoo, Moon KyungKim, Ji HoonYeon, Jong EunPark, Jong JaeKim, Jae SeonBak, Young Tae
Issue Date
Jan-2015
Publisher
Baishideng Publishing Group
Keywords
Butein; Colitis; Inflammatory bowel disease; Interleukin-6/signal transducer and activator of transcription 3; Matrix metalloproteinase-9
Citation
World Journal of Gastroenterology, v.21, no.2, pp.465 - 474
Indexed
SCIE
SCOPUS
Journal Title
World Journal of Gastroenterology
Volume
21
Number
2
Start Page
465
End Page
474
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54134
DOI
10.3748/wjg.v21.i2.465
ISSN
1007-9327
Abstract
AIM: To evaluate the effects of butein on inflammatory cytokines, matrix metalloproteinase-9 (MMP-9), and colitis in interleukin (IL)-10(-/-) mice. METHODS: To synchronize colitis, 8- to 10-wk-old IL-10(-/-) mice were fed pellet-chow containing piroxicam for 2 wk. Subsequently, phosphate-buffered saline or butein (1 mg/kg per day, ip) was injected for 4 wk. Histologic scores, inflammatory cytokines, MMP-9 and phosphorylated signal transducer and activator of transcription 3 (pSTAT3) expressions were analyzed in IL-10(-/-) mice and in Colo 205 cells. RESULTS: Butein reduced the colonic inflammatory score by > 50%. Expression levels of IL-6, IL-1 beta, interferon (IFN)-gamma and MMP-9 were decreased in the colons of mice exposed to butein, whereas other inflammatory cytokines (IL-17A, IL-21 and IL-22) were unchanged. Immunohistochemical staining for pSTAT3 and MMP-9 was significantly decreased in the butein-treated groups compared with the controls. Butein inhibited IL-6-induced activation of STAT3 in Colo 205 cells. CONCLUSION: Butein ameliorated colitis in IL-10(-/-) mice by regulating IL-6/STAT3 and MMP-9 activation.
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Bak, Young Tae
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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