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Cited 3 time in webofscience Cited 4 time in scopus
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Feasibility and effectiveness of endoscopic irreversible electroporation for the upper gastrointestinal tract: an experimental animal study

Authors
Jeon, Han JoChoi, Hyuk SoonKeum, BoraBang, Eun JooLee, Kang WonKim, Sang HyunYim, Sun YoungLee, Jae MinKim, Eun SunSeo, Yeon SeokJeen, Yoon TaeLee, Hong SikChun, Hoon JaiKim, Hong BaeKim, Jong Hyuk
Issue Date
28-Jul-2021
Publisher
NATURE PORTFOLIO
Citation
SCIENTIFIC REPORTS, v.11, no.1
Indexed
SCIE
SCOPUS
Journal Title
SCIENTIFIC REPORTS
Volume
11
Number
1
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54231
DOI
10.1038/s41598-021-94583-w
ISSN
2045-2322
Abstract
Irreversible electroporation (IRE) is a local non-thermal ablative technique currently used to treat solid tumors. Here, we investigated the clinical potency and safety of IRE with an endoscope in the upper gastrointestinal tract. Pigs were electroporated with recently designed endoscopic IRE catheters in the esophagus, stomach, and duodenum. Two successive strategies were introduced to optimize the electrical energy for the digestive tract. First, each organ was electroporated and the energy upscaled to confirm the upper limit energy inducing improper tissue results, including bleeding and perforation. Excluding the unacceptable energy from the first step, consecutive electroporations were performed with stepwise reductions in energy to identify the energy that damaged each layer. Inceptive research into inappropriate electrical intensity contributed to extensive hemorrhage and bowel perforation for each tissue above a certain energy threshold. However, experiments performed below the precluded energy accompanying hematoxylin and eosin staining and terminal deoxynucleotidyl transferase dUTP nick-end labeling assays showed that damaged mucosal area and depth significantly decreased with decreased energy. Relevant histopathology showed infiltration of inflammatory cells with pyknotic nuclei at the electroporated lesion. This investigation demonstrated the possibility of endoscopic IRE in mucosal dysplasia or early malignant tumors of the hollow viscus.
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Chun, Hoon Jai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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