Distinguishing quantitative EEG findings between adjustment disorder and major depressive disorder
- Lee, H.; Ko, Young Hoon; Jeong, Hyun Ghang; Han, Changsu; Kim, Yong Ku; Joe, Sook Haeng
- Issue Date
- ELSEVIER SCIENCE BV
- EUROPEAN NEUROPSYCHOPHARMACOLOGY, v.22, no.Suppl 2, pp.S233 - S233
- Journal Title
- EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Suppl 2
- Start Page
- End Page
- Purpose: Adjustment disorder (ADJ) is a common diagnosis.
However, it is difficult to distinguish ADJ from other major Axis
I disorders, such as major depressive disorder (MDD). The aim of
this study was to determine the distinguishing neurophysiological
characteristics between ADJ and MDD using quantitative analysis
of electroencephalogram (QEEG).
Methods: The subjects included 30 patients with ADJ and 51
patients with MDD. QEEG absolute power and coherence were
calculated for the delta, theta, alpha and beta bandwidths, assessed
at 8 pairs of electrodes in both hemispheres during a resting, eyesclosed condition.
Results: The mean ages of the ADJ group and the MDD group
were 38.4±11.8 years and 37.33±10.41 years, respectively. In the
ADJ group, health problems (53.3%) were the most common type
of predisposing stressor, followed by familial conflict (16.7%),
military problems (13.3%), interpersonal problems (10%) and
occupational problems (6.7%), in order. Comparing the mean absolute power value for every frequency band, there were significant
differences in the alpha and high-beta bands between the ADJ
and MDD groups, respectively, particularly in the right and left
frontocentral areas. The absolute alpha power was found to be
lower in the ADJ group than in the MDD group at Fp1 (p = 0.036),
Fp2 (p = 0.031), F3 (p = 0.025), F4 (p = 0.037), F7 (p = 0.042), F8
(p = 0.023), C3 (p = 0.039) and C4 (p = 0.034). The absolute highbeta power was also found to be lower in the ADJ group than in the
MDD group, particularly at both the right and left frontocentral
areas: at Fp1 (p = 0.035), Fp2 (p = 0.022), F3 (p = 0.029), F4
(p = 0.016), F7 (p = 0.022), F8 (p = 0.024), C3 (p = 0.019) and C4
(p = 0.028). In temporoparieatal areas, patients with ADJ showed
higher alpha power at T3 (p = 0.049), and higher high beta power
at T5 (p = 0.021), P3 (p = 0.028) and P4 (p = 0.071) compared to
patients with MDD. The values for intrahemispheric coherence
were higher in the MDD group than in the ADJ group for the 2
pairs of electrodes on the right side. The significant differences
in intrahemispheric coherence value were pronounced between
P4O2 for the delta band (p = 0.043) and the beta band (p = 0.009).
Interhemispheric coherence values were higher in the MDD group
than in the ADJ group that between F3F4 (p = 0.036) and T3T4
(p = 0.041) for the alpha band.
Conclusions: The differences in QEEG power and coherence in
our investigation suggest that underlying pathophysiologic mechanisms may be different between ADJ and MDD. QEEG might
be considered a useful adjunct to clinical differentiation between
ADJ and MDD.
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- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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