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Cited 14 time in webofscience Cited 15 time in scopus
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Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study

Authors
Kim, Ye EunKim, Min KyungSuh, Sang-ilKim, Ji Hyun
Issue Date
7-Sep-2021
Publisher
BioMed Central
Keywords
Migraine without aura; Low-frequency oscillation; Fractional amplitude of low-frequency fluctuation; Brainstem; Thalamus
Citation
BMC Neurology, v.21, no.1
Indexed
SCIE
SCOPUS
Journal Title
BMC Neurology
Volume
21
Number
1
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54352
DOI
10.1186/s12883-021-02374-7
ISSN
1471-2377
1471-2377
Abstract
Background Recent resting-state fMRI studies demonstrated functional dysconnectivity within the central pain matrix in migraineurs. This study aimed to investigate the spatial distribution and amplitude of low-frequency oscillations (LFOs) using fractional amplitude of low-frequency fluctuation (fALFF) analysis in migraine patients without aura, and to examine relationships between regional LFOs and clinical variables. Methods Resting-state fMRI data were obtained and preprocessed in 44 migraine patients without aura and 31 matched controls. fALFF was computed according to the original method, z-transformed for standardization, and compared between migraineurs and controls. Correlation analysis between regional fALFF and clinical variables was performed in migraineurs as well. Results Compared with controls, migraineurs had significant fALFF increases in bilateral ventral posteromedial (VPM) thalamus and brainstem encompassing rostral ventromedial medulla (RVM) and trigeminocervical complex (TCC). Regional fALFF values of bilateral VPM thalamus and brainstem positively correlated with disease duration, but not with migraine attack frequency or Migraine Disability Assessment Scale score. Conclusions We have provided evidence for abnormal LFOs in the brainstem including RVM/TCC and thalamic VPM nucleus in migraine without aura, implicating trigeminothalamic network oscillations in migraine pathophysiology. Our results suggest that enhanced LFO activity may underpin the interictal trigeminothalamic dysrhythmia that could contribute to the impairments of pain transmission and modulation in migraine. Given our finding of increasing fALFF in relation to increasing disease duration, the observed trigeminothalamic dysrhythmia may indicate either an inherent pathology leading to migraine headaches or a consequence of repeated attacks on the brain.
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