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A case report of a patient presented with skin ulcer after treatment of lenvatinibA case report of a patient presented with skin ulcer after treatment of lenvatinib

Other Titles
A case report of a patient presented with skin ulcer after treatment of lenvatinib
Authors
차세린정영걸최정완김태형김승영현종진정성우구자설임형준김동우
Issue Date
Sep-2021
Publisher
대한간암학회
Keywords
Lenvatinib mesylate; Skin ulcer; Hepatocellular carcinoma; Adverse drug event; Protein kinase inhibitor
Citation
대한간암학회지, v.21, no.2, pp.194 - 198
Indexed
KCI
Journal Title
대한간암학회지
Volume
21
Number
2
Start Page
194
End Page
198
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54534
DOI
10.17998/jlc.2021.09.20
ISSN
2288-8128
Abstract
A 60-year-old man diagnosed with unresectable hepatocellular carcinoma (HCC) presented to the hospital with pain in the perineal region. He had been taking lenvatinib every day for 2 months after he was diagnosed with HCC with metastases to the lymph node, small bowel mesentery, and retroperitoneal space. Enhanced abdominal computed tomography revealed mild elevation in intensity in the perineal subcutaneous tissue with subcutaneous emphysema. The patient was diagnosed with Common Terminology Criteria for Adverse Events grade 3, skin ulceration of stage IV with full-thickness skin loss and tissue necrosis in the muscular layer. The patient was taken off the medication with prescription of antibiotics, and after 3 weeks, the skin has fully recovered. This is the first report of an HCC patient who presented with a skin ulceration of stage IV after lenvatinib treatment. We recommend stopping the medication immediately and changing to alternative treatments with appropriate supportive care.
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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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