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THE RELATIONSHIP BETWEEN DIENOGEST (VISANNE (R)) AND DEPRESSIVE SYMPTOMS: A PROSPECTIVE COHORT STUDY

Authors
Choo, Sung PilCho, SiHyunShin, Jung-HoBae, NayoungAhn, So Hyun
Issue Date
Sep-2021
Publisher
ELSEVIER SCIENCE INC
Citation
Fertility and Sterility, v.116, no.3, pp E364 - E365
Indexed
SCIE
SCOPUS
Journal Title
Fertility and Sterility
Volume
116
Number
3
Start Page
E364
End Page
E365
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54645
DOI
10.1016/j.fertnstert.2021.07.979
ISSN
0015-0282
1556-5653
Abstract
Objective The purpose of this study was to determine the effects of dienogest (DNG) on depressive symptoms and anxiety symptoms among Korean women with endometriosis and to identify predictive factors of the psychological side effects of DNG in women with endometriosis. Materials and Methods We conducted survey on 50 women with pathologically confirmed endometriosis who were treated with DNG 2mg daily for 6 months at two different institutions in Korea between 2020 and 2021. We utilized The Center for Epidemiologic Studies-Depression Scale (CES-D, cut off >= 16) and Spielberger State-Trait Anxiety Inventory (STAI, State anxiety cutoff >= 52, Trait anxiety cutoff >= 54). The questionnaires were completed before and after 6 months of DNG treatment and the scores before and after treatment were compared using SAS (version 9.4, SAS Inc., Cary, NC, USA). For all analyses, differences were considered as statistically significant for p<0.05. Results Mean age and BMI of the participants were 33.2 ± 6.1, 22.26 ± 3.0, respectively. Before the treatment, the mean CES-D, state anxiety, and trait anxiety scores were 14.84 ± 8.64, 40.66 ± 11.43 and 40.62 ± 10.56, respectively. After 6 months of DNG use, the mean CES-D, state anxiety, and trait anxiety scores were 15.74 ± 8.27, 40.28 ± 10.72 and 41.48 ± 10.18, respectively, and the differences between before and after treatment were not statistically significant. The number of patients who had higher scores than cut-off score before treatment was 20 (40%) in CES-D, 11 (22%) in state anxiety and 8 (16%) in trait anxiety. After the treatment, number of patients above the cut- off scores in CES-D, state anxiety, and trait anxiety were 21 (42%), 8 (16%) and 7 / 50 (14%), respectively and the proportions of women in the risk of depression and anxiety before and after treatment were not significant. Among the women who had a CES-D score < 16 before treatment, 11 (36.7%) developed scores above 16 after treatment. Clinical characteristics of these patients were analyzed including age, BMI, and rAFS scores during surgery, but no significant differences were noted when compared with those who scored <16 before and after the treatment. Conclusions Although there was no statistical significance and no definite predictive factor for aggravation of depression and anxiety, depression tended to increase slightly after DNG use. Additional long-term and large scale prospective studies are needed to determine these findings. Before starting DNG use, healthcare providers should consider multidisciplinary approaches for psychological issues and inform the patients on the risks of depression and anxiety associated with the use of DNG. Impact Statement The results of this study could be useful in managing patients on the side effects of DNG, depression and anxiety, so that appropriate consultations could be given. View Abstract Copyright © 2021 Published by Elsevier Inc.
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