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Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation

Authors
Kim, SeongminLee, SanghoonPark, Hyun-TaeSong, Jae-YunKim, Tak
Issue Date
Oct-2021
Publisher
MDPI
Keywords
chemotherapy; gene; mutation; gonadotoxicity; fertility preservation; cryopreservation; oncofertility
Citation
Genes, v.12, no.10
Indexed
SCIE
SCOPUS
Journal Title
Genes
Volume
12
Number
10
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54694
DOI
10.3390/genes12101525
ISSN
2073-4425
Abstract
Chemotherapy-induced ovarian damage and fertility preservation in young patients with cancer are emerging disciplines. The mechanism of treatment-related gonadal damage provides important information for targeting prevention methods. The genomic aspects of ovarian damage after chemotherapy are not fully understood. Several studies have demonstrated that gene alterations related to follicular apoptosis or accelerated follicle activation are related to ovarian insufficiency and susceptibility to ovarian damage following chemotherapy. This may accelerate follicular apoptosis and follicle reservoir utilization and damage the ovarian stroma via multiple molecular reactions after chemotherapy. This review highlights the importance of genomic considerations in chemotherapy-induced ovarian damage and multidisciplinary oncofertility strategies for providing high-quality care to young female cancer patients.</p>
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Song, Jae Yun
Anam Hospital (Department of Obstetrics and Gynecology, Anam Hospital)
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