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Cited 4 time in webofscience Cited 6 time in scopus
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Clinical Events with Edoxaban in South Korean and Taiwanese Atrial Fibrillation Patients in Routine Clinical Practice

Authors
Choi, Eue-KeunLin, Wei-ShiangHwang, Gyo-SeungKirchhof, PaulusDe Caterina, RaffaeleChen, CathyUnverdorben, MartinWang, Chun-ChiehKim, Young-Hoon
Issue Date
Nov-2021
Publisher
MDPI
Keywords
atrial fibrillation; edoxaban; real-world data; Asia; ETNA
Citation
Journal of Clinical Medicine, v.10, no.22
Indexed
SCIE
SCOPUS
Journal Title
Journal of Clinical Medicine
Volume
10
Number
22
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/54881
DOI
10.3390/jcm10225337
ISSN
2077-0383
2077-0383
Abstract
Edoxaban is approved for stroke prevention in nonvalvular atrial fibrillation (AF) patients in numerous countries. Outcome data are sparse on edoxaban treatment in AF patients from routine clinical practice, especially in Asian patients. Global ETNA (Edoxaban in rouTine cliNical prActice) is a noninterventional study that integrates data from patients from multiple regional registries into one database. Here, we report the 1-year clinical events from AF patients receiving edoxaban in South Korea and Taiwan. Clinical events assessed included bleeding, strokes, systemic embolic events, transient ischemic attacks (TIAs), and all-cause and cardiovascular death. Overall, 2677 patients (mean (range) age 72 (66-78) years, male 59.7%, mean CHA(2)DS(2)-VASc score & PLUSMN; standard deviation 3.1 & PLUSMN; 1.4) were treated with 60 or 30 mg edoxaban and had 1-year follow-up data. The annualized event rates for major bleeding and clinically relevant non-major (CRNM) bleeding were 0.78% and 0.47%, respectively. Annualized event rates for ischemic stroke and hemorrhagic stroke were 0.90% and 0.19%, respectively. Event rates for major and CRNM bleeding and rates of ischemic stroke and TIA were higher in Taiwanese patients than in Korean patients. Event rates were low and similar to those found in other studies of edoxaban in Korean and Taiwanese AF patients, thus supporting the safety and effectiveness of edoxaban in this population.
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