Brain amyloid accumulation possibly exacerbates concurrent mild cognitive impairment with subthreshold depression in older adults: A 1-year follow-up study
- Youn, HyunChul; Hyung, Won Seok William; Kim, Junhyung; Lee, Eun Seong; Eo, Jae Seon; Han, Cheol E.; Han, Changsu; Kim, Seung-Hyun; Jeong, Hyun-Ghang
- Issue Date
- Elsevier BV
- Alzheimer disease; Amyloid; Cognitive dysfunction; Late-life depression; Memory; Positron emission tomography
- Journal of Affective Disorders, v.295, pp.93 - 100
- Journal Title
- Journal of Affective Disorders
- Start Page
- End Page
This study aimed to investigate the 1-year changes in neuropsychological test results in older adults with concomitant late-life depression (LLD) and mild cognitive impairment (MCI) according to the presence or absence of brain amyloidopathy.
All subjects underwent 18F‐florbetaben‐positron emission tomography and a standardized neuropsychological battery. The subjects were divided based on brain amyloidopathy and severity of depressive symptoms into the following groups: LLD-MCI-A(+), subthreshold depression (STD)-MCI-A(+), major depressive disorder (MDD)-MCI-A(+), LLD-MCI-A(-), STD-MCI-A(-), and MDD-MCI-A(-). After one year, follow-up neurocognitive tests were conducted. Fifty-nine participants completed both the baseline and 1-year follow-up neurocognitive tests.
In the LLD-MCI-A(+) group, the word list recall and word list recognition scores decreased during the follow-up period. The STD-MCI-A(+) group also showed a significant decrease in word list recall score and the score/Z-score of word list recognition. On the other hand, the word list recall Z-score improved at the 1-year follow-up in the LLD-MCI-A(-) group. In particular, the MDD-MCI-A(-) group showed significant increases in word list memory score/Z-score and word list recall Z-score during the follow-up period.
Considering that AD progresses slowly, a longer follow-up period may be required.
Our findings showed differences in the extent of change of neuropsychological test results depending on the severity of depressive symptoms and presence or absence of brain amyloidopathy. Our results suggest that clinicians might explore the underlying neuropathology when assessing older adults with concomitant depression and cognitive impairment, even if the symptoms of depression are not severe.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 2. Clinical Science > Department of Nuclear Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.